TRIP6 Antibody (D-11): sc-166311

TRIP6 Antibody (D-11) is a mouse monoclonal IgG3 antibody that detects TRIP6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIP6 is a LIM domain-containing protein that plays a critical role in cellular signaling and cytoskeletal organization, primarily localizing to focal adhesion plaques and actin filament bundles. TRIP6 is essential for mediating interactions between various signaling pathways, particularly in response to pro-inflammatory cytokines like tumor necrosis factor (TNF) and interleukin-1 (IL-1). Notably, TRIP6 interacts with receptor-interacting protein 2 (RIP2) and TRAF2, both of which are pivotal in TNF signaling pathways. TRIP6′s ability to facilitate the activation of nuclear factor kappa B (NFkappaB) in response to TNF, IL-1, and other stimuli underscores its importance in regulating inflammatory responses and cellular survival. Furthermore, TRIP6′s involvement in enhancing ERK activation through RIP2 and Nod1 pathways highlights its multifaceted role in signal transduction, making TRIP6 a significant target for research in inflammation and cancer biology. anti-TRIP6 antibody (D-11) is an invaluable tool for researchers investigating the intricate mechanisms of cellular signaling and adhesion.

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TRIP6 Antibody (D-11) References:

1. TRIP6 regulates p27 KIP1 to promote tumorigenesis.  |  Lin, VT., et al. 2013. Mol Cell Biol. 33: 1394-409. PMID: 23339869
2. TRIP6 regulates neural stem cell maintenance in the postnatal mammalian subventricular zone.  |  Lai, YJ., et al. 2014. Dev Dyn. 243: 1130-42. PMID: 25044744
3. Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization.  |  Lv, K., et al. 2015. J Neurosci. 35: 2559-71. PMID: 25673849
4. TRIP6, as a target of miR-7, regulates the proliferation and metastasis of colorectal cancer cells.  |  Ling, Y., et al. 2019. Biochem Biophys Res Commun. 514: 231-238. PMID: 31029422
5. TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer.  |  Zhu, L., et al. 2019. Biologics. 13: 101-110. PMID: 31354238
6. TRIP6 enhances stemness property of breast cancer cells through activation of Wnt/β-catenin.  |  Zhao, X., et al. 2020. Cancer Cell Int. 20: 51. PMID: 32082081
7. TRIP6 regulates the proliferation, migration, invasion and apoptosis of osteosarcoma cells by activating the NF-κB signaling pathway.  |  Liu, W., et al. 2020. Exp Ther Med. 19: 2317-2325. PMID: 32104300
8. TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation.  |  Wei, F. and Hao, Y. 2020. Int Immunopharmacol. 82: 106366. PMID: 32151960
9. ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines.  |  Daniel, P., et al. 2023. Genes (Basel). 14: PMID: 36833223
10. TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.  |  Lu, X., et al. 2023. J Hepatocell Carcinoma. 10: 1281-1293. PMID: 37554583

The preferred TRIP6 antibody is TRIP6 Antibody (F-5): sc-365122.