TRIP6 Antibody (C-5): sc-166330

TRIP6 Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects TRIP6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIP6 is a crucial protein that plays a significant role in cellular signaling pathways, particularly in inflammation and immune responses. TRIP6 is predominantly localized in the cytoplasm and interacts with various signaling molecules, including receptor-interacting protein 2 (RIP2) and tumor necrosis factor receptor-associated factor 2 (TRAF2). TRIP6 interaction with these proteins is vital for activating the NF-kappaB pathway, which regulates immune responses and inflammation. By facilitating NF-kappaB activation in response to stimuli such as tumor necrosis factor (TNF) and interleukin-1 (IL-1), TRIP6 plays a pivotal role in modulating cellular responses to stress and injury. TRIP6′s ability to enhance signaling pathways underscores TRIP6′s importance in maintaining cellular homeostasis and potential implications in various diseases, including cancer and autoimmune disorders. With specificity and versatility, anti-TRIP6 antibody (C-5) serves as an invaluable tool for researchers investigating TRIP6′s intricate roles in cellular signaling and disease mechanisms.

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TRIP6 Antibody (C-5) References:

1. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.  |  Xu, J., et al. 2004. J Biol Chem. 279: 10459-68. PMID: 14688263
2. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways.  |  Li, L., et al. 2005. J Cell Sci. 118: 555-63. PMID: 15657077
3. PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.  |  Lai, YJ., et al. 2007. J Biol Chem. 282: 24381-7. PMID: 17591779
4. The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.  |  Lai, YJ., et al. 2010. Mol Cell Biol. 30: 5582-96. PMID: 20876301
5. Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma.  |  Miao, X., et al. 2016. Tumour Biol. 37: 1369-78. PMID: 26298725
6. TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.  |  Gou, H., et al. 2019. Cancer Res. 79: 3332-3346. PMID: 31018940
7. MiR-485-3p modulates neural stem cell differentiation and proliferation via regulating TRIP6 expression.  |  Gu, J., et al. 2020. J Cell Mol Med. 24: 398-404. PMID: 31730275
8. TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation.  |  Li, MY., et al. 2024. FASEB J. 38: e23501. PMID: 38411462
9. High Expression Level of TRIP6 is Correlated with Poor Prognosis in Colorectal Cancer and Promotes Tumor Cell Proliferation and Migration.  |  Ren, H., et al. 2025. Biochem Genet. 63: 261-280. PMID: 38430448
10. The TRIP6/LATS1 complex constitutes the tension sensor of α-catenin/vinculin at both bicellular and tricellular junctions.  |  Xie, L., et al. 2024. Eur J Cell Biol. 103: 151426. PMID: 38805800

The preferred TRIP6 antibody is TRIP6 Antibody (F-5): sc-365122.