TRIP15 Antibody (42): sc-136511

TRIP15 Antibody (42) is a mouse monoclonal IgG2b kappa light chain antibody that detects TRIP15 protein of mouse, rat, human, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-TRIP15 antibody (42) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). TRIP15 protein plays a crucial role in cellular regulation as part of the COP9 signalosome, a multi-subunit complex essential for modulating protein degradation pathways. TRIP15, along with Cops2 and Alien, forms the second subunit (CSN2) of this complex, which regulates Skp1-cullin-F-box protein (SCF) ubiquitin ligases. By deconjugating Nedd8 from the Cul1 component of SCF, TRIP15 helps inhibit ligase activity, impacting cell cycle by preventing progression from G1 to S phase. Structural features of TRIP15, including an acidic region at N-terminus, a putative zinc finger at C-terminus, and a central hydrophobic core flanked by two potential alpha-helical structures, along with a nuclear localization signal, are vital for function and interaction with other proteins. These characteristics underscore TRIP15′s importance in maintaining cellular homeostasis and regulating critical signaling pathways.

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TRIP15 Antibody (42) References:

1. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome.  |  Cohen, H., et al. 2000. J Biol Chem. 275: 39081-9. PMID: 10991940
2. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.  |  Yang, X., et al. 2002. Curr Biol. 12: 667-72. PMID: 11967155
3. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2.  |  Akiyama, H., et al. 2003. J Biol Chem. 278: 10752-62. PMID: 12522100
4. Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells.  |  Akiyama, H., et al. 2003. Brain Res Dev Brain Res. 140: 45-56. PMID: 12524175
5. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.  |  Lykke-Andersen, K., et al. 2003. Mol Cell Biol. 23: 6790-7. PMID: 12972599
6. Identification and characterization of TRIP8 gene in silico.  |  Katoh, M. and Katoh, M. 2003. Int J Mol Med. 12: 817-21. PMID: 14533015

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRIP15 Antibody (42) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TRIP15 Antibody (42) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRIP15 Antibody (42) Specifications

Alternate Product Name: TRIP15

Product Clone Name: 42

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 172-299

Epitope Target: TRIP15

Epitope Species: human

Product Reactivity/Detection: TRIP15

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TRIP15 Antibody (42): AC: Agarose, HRP: Horseradish Peroxidase