Trimethyl Histone H3 Antibody (3G3): sc-517570
- Trimethyl Histone H3 Antibody (3G3) is a mouse monoclonal IgG provided at 100 µg/ml
- raised against Lys 79 trimethylated Histone H3 of human origin
- recommended for detection of Lys 79 trimethylated Histone H3 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Trimethyl Histone H3 Antibody (3G3). This work is in progress.
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Trimethyl Histone H3 Antibody (3G3) is a mouse monoclonal IgG antibody that detects Trimethyl Histone H3 in mouse, rat, and human samples through western blotting (WB). Trimethyl Histone H3 plays a crucial role in gene expression and chromatin structure regulation as a key component of the nucleosome, which packages DNA into a compact, organized form within the nucleus. Trimethylation of histone H3, particularly at lysine 4 (H3K4me3), associates with active transcription and appears at promoters of actively expressed genes, serving as an important marker for identifying transcriptionally active genome regions. This post-translational modification influences chromatin accessibility and serves as a binding site for various transcription factors and chromatin remodeling complexes, facilitating transcriptional machinery recruitment. Anti-Trimethyl Histone H3 antibody (3G3) specifically recognizes this modified form of histone H3, enabling researchers to study dynamics in various biological processes, including development, differentiation, and disease states, providing valuable insights into epigenetic regulation of gene expression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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Trimethyl Histone H3 Antibody (3G3) References:
- Assembly of additional heterochromatin distinct from centromere-kinetochore chromatin is required for de novo formation of human artificial chromosome. | Nakashima, H., et al. 2005. J Cell Sci. 118: 5885-98. PMID: 16339970
- Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer. | Okino, ST., et al. 2006. Cancer Res. 66: 7420-8. PMID: 16885337
- The nuclear periphery of embryonic stem cells is a transcriptionally permissive and repressive compartment. | Luo, L., et al. 2009. J Cell Sci. 122: 3729-37. PMID: 19773359
- Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. | Yu, S., et al. 2010. PLoS One. 5: e8579. PMID: 20062804
- A simple method for improving the specificity of anti-methyl histone antibodies. | Connor, C., et al. 2010. Epigenetics. 5: 392-5. PMID: 20458167
- Inhibition of osteogenic differentiation of human adipose-derived stromal cells by retinoblastoma binding protein 2 repression of RUNX2-activated transcription. | Ge, W., et al. 2011. Stem Cells. 29: 1112-25. PMID: 21604327
- Epigenetic regulation of vascular endothelial growth factor a dynamic expression in transitional cell carcinoma. | Ping, SY., et al. 2013. Mol Carcinog. 52: 568-79. PMID: 22392726
- Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. | Bai, G., et al. 2015. Hum Mol Genet. 24: 1441-56. PMID: 25480889
- Expression and Dendritic Trafficking of BDNF-6 Splice Variant are Impaired in Knock-In Mice Carrying Human BDNF Val66Met Polymorphism. | Mallei, A., et al. 2015. Int J Neuropsychopharmacol. 18: PMID: 26108221
- H3K4 Trimethylation Mediate Hyperhomocysteinemia Induced Neurodegeneration via Suppressing Histone Acetylation by ANP32A. | Chai, GS., et al. 2024. Mol Neurobiol. 61: 6788-6804. PMID: 38351418
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trimethyl Histone H3 Antibody (3G3) | sc-517570 | 100 µg/ml | $322.00 |