TRIM36 Antibody (SS-03): sc-100881

TRIM36 Antibody (SS-03) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRIM36 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TRIM36 (SS-03) antibody is available as non-conjugated anti-TRIM36 antibody. TRIM36, also known as RNF98 (RING finger protein 98), HAPRIN (haploid germ cell-specific RBCC protein), or RBCC728, is a 728 amino acid protein that belongs to the TRIM/RBCC (Ring finger, B box, coiled-coil) family. TRIM36 is predominantly expressed in prostate, testis, and brain, with weaker expression observed in heart, kidney, and lung. TRIM36 contains two B box-type zinc fingers, a SPRY domain, a coiled-coil domain, a fibronectin type-III domain, and a RING-type zinc finger, which is crucial for mediating protein-protein and protein-DNA interactions due to zinc-chelating activity. TRIM36 localizes to cytoplasm and acrosomal region of germ cells and mature sperm, indicating a significant role in acrosome reaction and fertilization processes. TRIM36 has been found to be overexpressed in prostate cancer, suggesting potential involvement in prostate tumorigenesis, making TRIM36 a valuable target for research in cancer biology and reproductive health.

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TRIM36 Antibody (SS-03) References:

1. The tripartite motif family identifies cell compartments.  |  Reymond, A., et al. 2001. EMBO J. 20: 2140-51. PMID: 11331580
2. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction.  |  Kitamura, K., et al. 2003. J Biol Chem. 278: 44417-23. PMID: 12917430
3. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3.  |  Balint, I., et al. 2004. Gene. 332: 45-50. PMID: 15145053
4. Identification of human HAPRIN potentially involved in the acrosome reaction.  |  Kitamura, K., et al. 2005. J Androl. 26: 511-8. PMID: 15955891
5. The RING-finger protein haprin: domains and function in the acrosome reaction.  |  Kitamura, K., et al. 2005. Curr Protein Pept Sci. 6: 567-74. PMID: 16381605
6. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.  |  Short, KM. and Cox, TC. 2006. J Biol Chem. 281: 8970-80. PMID: 16434393
7. TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation.  |  He, Z., et al. 2017. Environ Pollut. 225: 93-103. PMID: 28359976
8. Microtubular TRIM36 E3 Ubiquitin Ligase in Embryonic Development and Spermatogenesis.  |  Mascaro, M., et al. 2022. Cells. 11: PMID: 35053362
9. TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/β-catenin signaling pathway.  |  Zhao, B., et al. 2022. Hum Cell. 35: 1487-1498. PMID: 35768649
10. TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p.  |  Yu, S., et al. 2022. Biochem Biophys Res Commun. 628: 1-10. PMID: 36058131
11. Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency.  |  Zhao, X., et al. 2023. Cancer Sci. 114: 2445-2459. PMID: 36799474
12. FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.  |  Liu, X., et al. 2023. Adv Sci (Weinh). 10: e2304521. PMID: 37875418

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRIM36 Antibody (SS-03) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TRIM36 Antibody (SS-03) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRIM36 Antibody (SS-03) Specifications

Alternate Product Name: TRIM36

Product Clone Name: SS-03

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 391-500

Epitope Target: TRIM36

Epitope Species: human

Product Reactivity/Detection: TRIM36

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TRIM36 Antibody (SS-03): N/A