Triiodothyronine Antibody (ME-124): sc-57481

Triiodothyronine Antibody (ME-124) is a mouse monoclonal IgG2b kappa light chain antibody that detects Triiodothyronine in non-species reactive applications such as enzyme-linked immunosorbent assay (ELISA). Anti-Triiodothyronine antibody (ME-124) is available as a non-conjugated format. Triiodothyronine (T3) is a crucial thyroid hormone composed of a tyrosine backbone with three iodine atoms, playing a vital role in regulating numerous physiological processes throughout the body. T3 is particularly important for maintaining metabolic homeostasis, influencing body temperature, growth, and heart rate. T3 exerts effects by easily penetrating cell membranes and binding to nuclear receptors, which subsequently modulate gene expression to enhance basal metabolic rate and increase sensitivity to catecholamines. T3 is involved in regulating protein, fat, and carbohydrate metabolism, making T3 essential for energy balance and overall metabolic health. T3 also plays a significant role in cell development and differentiation, underscoring T3′s importance in growth and development. An imbalance in T3 levels, such as in hyperthyroidism, can lead to serious health issues, highlighting the necessity of precise regulation of this hormone in the body.

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Triiodothyronine Antibody (ME-124) References:

1. [Triiodothyronine and thyroxin binding to red blood cells in children and adolescents with thyroid cancer].  |  Fedorovich, EI. and Demidchik, IuE. 2002. Vopr Onkol. 48: 661-3. PMID: 12530259
2. Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line.  |  Kariv, R., et al. 2003. Liver Int. 23: 187-93. PMID: 12955882
3. Effects of triiodothyronine and estrogen administration on bone mass, mineral content and bone strength in male rats.  |  Broulik, PD., et al. 2003. Horm Metab Res. 35: 527-31. PMID: 14517768
4. 3,5,3'-Triiodothyronine down-regulates Fas and Fas ligand expression and suppresses caspase-3 and poly (adenosine 5'-diphosphate-ribose) polymerase cleavage and apoptosis in early placental extravillous trophoblasts in vitro.  |  Laoag-Fernandez, JB., et al. 2004. J Clin Endocrinol Metab. 89: 4069-77. PMID: 15292350
5. Characteristics of 3,5,3'-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response.  |  Shimada, N. and Yamauchi, K. 2004. J Endocrinol. 183: 627-37. PMID: 15590988
6. Effective methimazole dose for childhood Graves' disease and use of free triiodothyronine combined with concurrent thyroid-stimulating hormone level to identify mild hyperthyroidism and delayed pituitary recovery.  |  Slyper, AH., et al. 2005. J Pediatr Endocrinol Metab. 18: 597-602. PMID: 16042328
7. Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine.  |  Olson, RD., et al. 2005. Cardiovasc Toxicol. 5: 269-83. PMID: 16244372
8. Triiodothyronine acutely increases blood flow in the ventricles and kidneys of anesthesized rabbits.  |  Kimura, K., et al. 2006. Thyroid. 16: 357-60. PMID: 16646681
9. Psychological well-being correlates with free thyroxine but not free 3,5,3'-triiodothyronine levels in patients on thyroid hormone replacement.  |  Saravanan, P., et al. 2006. J Clin Endocrinol Metab. 91: 3389-93. PMID: 16804044

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Triiodothyronine Antibody (ME-124) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Triiodothyronine Antibody (ME-124) Specifications

Alternate Product Name: Triiodothyronine

Product Clone Name: ME-124

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Triiodothyronine

Epitope Species:

Product Reactivity/Detection: Triiodothyronine

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Triiodothyronine Antibody (ME-124): N/A