trichoplein Antibody (G-2): sc-515025
- trichoplein Antibody (G-2) is a mouse monoclonal IgG1 κ trichoplein antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 94-201 mapping within an internal region of trichoplein of human origin
- trichoplein Antibody (G-2) is recommended for detection of trichoplein of human origin by WB, IP, IF and ELISA
- Anti-trichoplein Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for trichoplein Antibody (G-2) for WB applications. These reagents are now offered in bundles with trichoplein Antibody (G-2) (see ordering information below).
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SEE ALSO...
trichoplein Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects trichoplein protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-trichoplein antibody (G-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Trichoplein, also known as THCP (trichoplein keratin filament-binding protein) or mitostatin, is a 498 amino acid protein that plays a crucial role as a tumor suppressor by inhibiting cell growth and promoting apoptosis during cellular stress. Localization within the cytoplasm, mitochondria, and cell membrane is significant, as trichoplein is expressed at high levels in breast epithelial cells, normal urothelial cells, skeletal muscle, liver, testis, heart, and kidney, while showing reduced expression in advanced bladder and breast carcinoma. Trichoplein interacts with various cytokeratins, including Cytokeratin 5, 6, 8, 14, 16, and 18, which are essential for the structural stability of epithelial cells. Encoded by a gene located on human chromosome 12q24.11, trichoplein is a member of the THCP family, highlighting its relevance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
trichoplein Antibody (G-2) References:
- Identification of trichoplein, a novel keratin filament-binding protein. | Nishizawa, M., et al. 2005. J Cell Sci. 118: 1081-90. PMID: 15731013
- Fundamentals of ICANL accreditation. | Katanick, SL. and,. 2005. J Nucl Med Technol. 33: 19-23. PMID: 15731016
- Outpatient therapeutic 131I for thyroid cancer. | Panzegrau, B., et al. 2005. J Nucl Med Technol. 33: 28-30. PMID: 15731017
- Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report. | Yu, JQ., et al. 2005. J Nucl Med Technol. 33: 31-3. PMID: 15731018
- MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. | Vecchione, A., et al. 2009. Oncogene. 28: 257-69. PMID: 18931701
- Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. | Cerqua, C., et al. 2010. EMBO Rep. 11: 854-60. PMID: 20930847
- Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. | Ibi, M., et al. 2011. J Cell Sci. 124: 857-64. PMID: 21325031
- Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells. | Lauriola, A., et al. 2020. Cancers (Basel). 12: PMID: 32316593
- Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. | Martello, A., et al. 2020. EMBO Rep. 21: e48192. PMID: 32337819
- Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly. | Huang, M., et al. 2022. J Cell Physiol. 237: 2703-2712. PMID: 35147977
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trichoplein Antibody (G-2) | sc-515025 | 200 µg/ml | $322.00 | |||
trichoplein Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-531270 | 200 µg Ab; 10 µg BP | $361.00 | |||
trichoplein Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-524909 | 200 µg Ab, 40 µg BP | $361.00 | |||
trichoplein Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-544461 | 200 µg Ab; 20 µg BP | $361.00 | |||
trichoplein Antibody (G-2) AC | sc-515025 AC | 500 µg/ml, 25% agarose | $424.00 | |||
trichoplein Antibody (G-2) HRP | sc-515025 HRP | 200 µg/ml | $322.00 | |||
trichoplein Antibody (G-2) FITC | sc-515025 FITC | 200 µg/ml | $336.00 | |||
trichoplein Antibody (G-2) PE | sc-515025 PE | 200 µg/ml | $349.00 | |||
trichoplein Antibody (G-2) Alexa Fluor® 488 | sc-515025 AF488 | 200 µg/ml | $364.00 | |||
trichoplein Antibody (G-2) Alexa Fluor® 546 | sc-515025 AF546 | 200 µg/ml | $364.00 | |||
trichoplein Antibody (G-2) Alexa Fluor® 594 | sc-515025 AF594 | 200 µg/ml | $364.00 | |||
trichoplein Antibody (G-2) Alexa Fluor® 647 | sc-515025 AF647 | 200 µg/ml | $364.00 | |||
trichoplein Antibody (G-2) Alexa Fluor® 680 | sc-515025 AF680 | 200 µg/ml | $364.00 | |||
trichoplein Antibody (G-2) Alexa Fluor® 790 | sc-515025 AF790 | 200 µg/ml | $364.00 |