TRF2 Antibody (36): sc-136110
- TRF2 Antibody (36) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 316-427 of TRF2 of human origin
- recommended for detection of TRF2 of human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRF2 Antibody (36). This work is in progress.
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TRF2 Antibody (36) is a mouse monoclonal IgG1 antibody that detects TRF2 in human and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TRF2, also known as telomeric repeat binding factor 2, plays a crucial role in maintaining telomere integrity by protecting chromosome ends from end-to-end fusions, which is vital for genomic stability. TRF2 is primarily located in the nucleolus during the G0 and S phases of the cell cycle, where TRF2 is involved in regulating telomere length and structure. As cells enter the G2 phase, TRF2 disperses from the nucleolus, and during mitosis, TRF2 relocates from condensed chromosomes back to the nucleolus at cytokinesis. Proper localization and function of TRF2 are essential for preventing cellular senescence and immortalization, particularly in tumor cells, where down-regulation of TRF2 can lead to malignant progression. Anti-TRF2 antibody (36) is an invaluable tool for researchers studying telomere biology and its implications in cancer and aging.
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TRF2 Antibody (36) References:
- Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance. | Walker, JR. and Zhu, XD. 2012. Mech Ageing Dev. 133: 421-34. PMID: 22634377
- TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. | Frescas, D. and de Lange, T. 2014. Mol Cell Biol. 34: 1349-62. PMID: 24469404
- TRF2 recruits ORC through TRFH domain dimerization. | Higa, M., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 191-201. PMID: 27836746
- The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response. | Imran, SAM., et al. 2021. Int J Mol Sci. 22: PMID: 34576063
- TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress. | Higa, M., et al. 2021. Nucleic Acids Res. 49: 12234-12251. PMID: 34761263
- TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhang. | Paul, T., et al. 2021. Nucleic Acids Res. 49: 12377-12393. PMID: 34850123
- Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. | Storchova, R., et al. 2023. Nucleic Acids Res. 51: 1154-1172. PMID: 36651296
- Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway. | Zhou, M., et al. 2024. Molecules. 29: PMID: 38202844
- Exploring TRF2-Dependent DNA Distortion Through Single-DNA Manipulation Studies. | Zhao, X., et al. 2024. Commun Biol. 7: 148. PMID: 38310140
- Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres. | Khayat, F., et al. 2024. Nucleic Acids Res. 52: 7704-7719. PMID: 38884214
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRF2 Antibody (36) | sc-136110 | 50 µg/0.5 ml | $322.00 |