TRESK Antibody (E-2): sc-514525

TRESK Antibody (E-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects TRESK protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRESK (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRESK protein, known as TWIK-related spinal cord K+ channel, plays a crucial role in regulating neuronal excitability and is particularly important in the context of anesthetic action in the central nervous system. Located in the plasma membrane of neurons, TRESK contributes to the resting membrane potential and influences neuronal cell excitability. TRESK activation is mediated by calcium signals from calcineurin, a calcium/calmodulin-dependent phosphatase, and shows notable sensitivity to zinc ions. This zinc sensitivity allows TRESK to integrate various intracellular signals, thereby modulating neuronal responses to external stimuli, including effects of inhaled anesthetics. TRESK′s ability to mediate these effects highlights potential therapeutic applications in conditions involving altered neuronal excitability, such as chronic pain and epilepsy.

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TRESK Antibody (E-2) References:

1. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.  |  Czirják, G., et al. 2004. J Biol Chem. 279: 18550-8. PMID: 14981085
2. Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family.  |  Kang, D., et al. 2004. J Biol Chem. 279: 28063-70. PMID: 15123670
3. Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.  |  Liu, C., et al. 2004. Anesth Analg. 99: 1715-1722. PMID: 15562060
4. Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK.  |  Kang, D., et al. 2005. J Physiol. 564: 103-16. PMID: 15677687
5. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.  |  Keshavaprasad, B., et al. 2005. Anesth Analg. 101: 1042-1049. PMID: 16192517
6. Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.  |  Czirják, G. and Enyedi, P. 2006. Mol Pharmacol. 69: 1024-32. PMID: 16354767
7. TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.  |  Kang, D. and Kim, D. 2006. Am J Physiol Cell Physiol. 291: C138-46. PMID: 16495368
8. Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.  |  Czirják, G. and Enyedi, P. 2006. J Biol Chem. 281: 14677-82. PMID: 16569637
9. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers.  |  Brosnan, R., et al. 2006. Anesth Analg. 103: 86-91, table of contents. PMID: 16790632
10. TRESK channel as a potential target to treat T-cell mediated immune dysfunction.  |  Han, J. and Kang, D. 2009. Biochem Biophys Res Commun. 390: 1102-5. PMID: 19852929
11. TRESK: the lone ranger of two-pore domain potassium channels.  |  Enyedi, P., et al. 2012. Mol Cell Endocrinol. 353: 75-81. PMID: 22115960
12. The Background K+ Channel TRESK in Sensory Physiology and Pain.  |  Andres-Bilbe, A., et al. 2020. Int J Mol Sci. 21: PMID: 32717813

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRESK Antibody (E-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TRESK Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRESK Antibody (E-2) Specifications

Alternate Product Name: TRESK

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-48

Epitope Target: TRESK

Epitope Species: mouse

Product Reactivity/Detection: TRESK

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TRESK Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin