TRB-3 Antibody (E-7): sc-514455

TRB-3 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects TRB-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRB-3, also known as tribbles 3 or neuronal cell death-inducible protein kinase, plays a critical role in disrupting insulin signaling by directly binding to Akt kinases, thereby inhibiting their activation. This mechanism contributes to insulin resistance, a key factor in the development of type II diabetes. TRB-3 is predominantly expressed in the liver, pancreas, peripheral blood leukocytes, and bone marrow, highlighting TRB-3′s significance in metabolic regulation and cellular signaling pathways. TRB-3′s interaction with ATF4 inhibits transcriptional activation, further influencing the regulation of MAP kinases. In diabetic models, elevated levels of TRB-3 RNA and protein have been observed, underscoring TRB-3′s potential as a biomarker for insulin resistance and metabolic disorders. Anti-TRB-3 antibody (E-7) serves as an essential tool for researchers investigating the complexities of insulin signaling and diabetes-related mechanisms.

The preferred TRB-3 antibody is TRB-3 Antibody (B-2): sc-390242.