transgelin Antibody (1B8): sc-58867

Transgelin Antibody (1B8) is a mouse monoclonal IgG1 light chain antibody that detects transgelin in mouse, rat, human, bovine, and porcine samples through applications such as western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Transgelin, also known as SM22a, plays a crucial role in regulating smooth muscle contraction and maintaining cytoskeletal structural integrity. Transgelin (1B8) antibody targets proteins primarily located in smooth muscle cell cytoplasm, where transgelin interacts with actin filaments to promote actin gel formation vital for cellular shape and motility. Anti-transgelin antibody (1B8) recognizes proteins that bind actin at a ratio of 1:6 actin monomers, highlighting transgelin′s importance in cytoskeletal dynamics critical for various physiological processes, including vascular development and injury response. Notably, transgelin expression decreases in several transformed cell lines, suggesting transgelin monitoring could serve as an early biomarker for cellular transformation and cancer progression. With diverse applications and significant biological implications, transgelin monoclonal antibody (1B8) serves as an invaluable tool for researchers studying smooth muscle biology and related pathologies.

The preferred transgelin antibody is transgelin Antibody (6G6): sc-53932.