Transaldolase Antibody (B-11): sc-376203
- Transaldolase Antibody (B-11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Transaldolase of human origin
- recommended for detection of Transaldolase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Transaldolase Antibody (B-11). This work is in progress.
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Transaldolase Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects Transaldolase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Transaldolase plays a crucial role in the nonoxidative phase of the pentose phosphate pathway, where it is essential for the generation of NADPH, a vital cofactor in anabolic reactions and redox balance. This enzyme not only contributes to the production of ribose-5-phosphate, which is necessary for nucleic acid synthesis, but also supports lipid biosynthesis, thereby influencing cell growth, differentiation, and survival. The importance of Transaldolase is particularly highlighted in the context of male fertility, as deficiencies in this enzyme can lead to significant reproductive issues due to impaired sperm structure and function. Furthermore, mutations in the gene encoding Transaldolase have been implicated in various health conditions, including multiple sclerosis, hepatosplenomegaly, and skin telangiectases, underscoring Transaldolase′s relevance in both metabolic pathways and disease states. Anti-Transaldolase antibody (B-11) is an invaluable tool for researchers investigating these critical biological processes and their implications in health and disease.
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Transaldolase Antibody (B-11) References:
- ZNF143 mediates basal and tissue-specific expression of human transaldolase. | Grossman, CE., et al. 2004. J Biol Chem. 279: 12190-205. PMID: 14702349
- Transaldolase exchange and its effects on measurements of gluconeogenesis in humans. | Basu, R., et al. 2011. Am J Physiol Endocrinol Metab. 300: E296-303. PMID: 21062960
- Novel association of early onset hepatocellular carcinoma with transaldolase deficiency. | Leduc, CA., et al. 2014. JIMD Rep. 12: 121-7. PMID: 24097415
- Long-Term Systematic Monitoring of Four Polish Transaldolase Deficient Patients. | Lipiński, P., et al. 2018. JIMD Rep. 42: 79-87. PMID: 29292491
- Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers. | Ding, Y., et al. 2018. Nat Commun. 9: 4274. PMID: 30323337
- Form III RubisCO-mediated transaldolase variant of the Calvin cycle in a chemolithoautotrophic bacterium. | Frolov, EN., et al. 2019. Proc Natl Acad Sci U S A. 116: 18638-18646. PMID: 31451656
- GSM2, a transaldolase, contributes to reactive oxygen species homeostasis in Arabidopsis. | Zheng, M., et al. 2020. Plant Mol Biol. 104: 39-53. PMID: 32564178
- Successful Liver Transplantation in Two Polish Brothers with Transaldolase Deficiency. | Stefanowicz, M., et al. 2021. Children (Basel). 8: PMID: 34572178
- Chances of Liver Transplantation in a Patient With Transaldolase Deficiency Complicated by Hepatopulmonary Syndrome. | Fallata, E., et al. 2023. Cureus. 15: e35150. PMID: 36949991
- Rational Design of l-Threonine Transaldolase-Mediated System for Enhanced Florfenicol Intermediate Production. | Xi, Z., et al. 2024. J Agric Food Chem. 72: 461-474. PMID: 38153324
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Transaldolase Antibody (B-11) | sc-376203 | 200 µg/ml | $322.00 |