TRAF5 Antibody (E-5): sc-74503

TRAF5 Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects TRAF5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAF5 is a crucial member of the TNF receptor-associated factor (TRAF) protein family, which plays a significant role in mediating signal transduction from the tumor necrosis factor (TNF) receptor superfamily. TRAF5 is primarily located in the cytoplasm, where TRAF5 forms complexes with various receptors, including CD40, CD27, and CD30, facilitating the activation of downstream signaling pathways such as NF-kappa B. TRAF5 functions are vital for regulating immune responses and promoting cell survival, particularly in osteoclastogenesis, where TRAF5 influences the differentiation and activity of osteoclasts, the cells responsible for bone resorption. TRAF5 can undergo post-translational modifications, such as ubiquitination, which can affect stability and interaction with other signaling molecules, thereby modulating activity in immune signaling pathways. Anti-TRAF5 antibody (E-5) is an essential tool for researchers studying these complex signaling mechanisms and their implications in various diseases, including autoimmune disorders and cancer.

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TRAF5 Antibody (E-5) References:

1. TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation.  |  Missiou, A., et al. 2010. Circ Res. 107: 757-66. PMID: 20651286
2. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions.  |  Hildebrand, JM., et al. 2011. Immunol Rev. 244: 55-74. PMID: 22017431
3. TRAF5 negatively regulates TLR signaling in B lymphocytes.  |  Buchta, CM. and Bishop, GA. 2014. J Immunol. 192: 145-50. PMID: 24259503
4. TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behçet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study.  |  Xiang, Q., et al. 2014. PLoS One. 9: e84214. PMID: 24416204
5. TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.  |  Wang, X., et al. 2015. J Biol Chem. 290: 29086-94. PMID: 26453305
6. TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors.  |  Kobayashi, S., et al. 2020. Biochem Biophys Res Commun. 521: 353-359. PMID: 31668809
7. TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells.  |  Phung, HT., et al. 2020. Immunohorizons. 4: 129-139. PMID: 32156688
8. TRAF5 protects against myocardial ischemia reperfusion injury via AKT signaling.  |  Xu, W., et al. 2020. Eur J Pharmacol. 878: 173092. PMID: 32234528
9. TRAF5 promotes the occurrence and development of colon cancer via the activation of PI3K/AKT/NF-κB signaling pathways.  |  Sun, G., et al. 2020. J Biol Regul Homeost Agents. 34: 1257-1268. PMID: 32911926
10. Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling.  |  Wu, G., et al. 2023. PeerJ. 11: e15551. PMID: 37366426

The preferred TRAF5 antibody is TRAF5 Antibody (E-4): sc-74502.