TRAF4 Antibody (B-9): sc-390232
- TRAF4 Antibody (B-9) is a mouse monoclonal IgG1 κ TRAF4 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 40-111 of TRAF4 of human origin
- TRAF4 Antibody (B-9) is recommended for detection of TRAF4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TRAF4 Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRAF4 Antibody (B-9) for WB applications. These reagents are now offered in bundles with TRAF4 Antibody (B-9) (see ordering information below).
TRAF4 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRAF4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAF4 (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRAF4 protein plays a crucial role in cellular signaling pathways, particularly in the context of the tumor necrosis factor (TNF) receptor superfamily, which is essential for mediating immune responses and inflammation. TRAF4, originally known as CART1, is specifically expressed in breast carcinomas and is localized to the nucleus, where TRAF4 is involved in the regulation of gene expression in response to TNF receptor activation. This nuclear localization suggests TRAF4 may influence the transcriptional activity of target genes that are critical for cell survival and proliferation, particularly in cancerous tissues. Understanding TRAF4 function and localization is vital for elucidating TRAF4′s role in tumorigenesis and potential therapeutic targeting in cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAF4 Antibody (B-9) References:
- MEKK4 is an effector of the embryonic TRAF4 for JNK activation. | Abell, AN. and Johnson, GL. 2005. J Biol Chem. 280: 35793-6. PMID: 16157600
- Different activation of TRAF4 and TRAF6 in inflammatory bowel disease. | Shen, J., et al. 2013. Mediators Inflamm. 2013: 647936. PMID: 23431243
- Re: TRAF4-Mediated Ubiquitination of NGF Receptor TrkA Regulates Prostate Cancer Metastasis. | Atala, A. 2019. J Urol. 201: 230. PMID: 30634343
- An IL-17-EGFR-TRAF4 axis contributes to the alleviation of lung inflammation in severe influenza. | Dutta, A., et al. 2023. Commun Biol. 6: 600. PMID: 37270623
- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. | Tomasetto, C., et al. 1995. Genomics. 28: 367-76. PMID: 7490069
- TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. | Rothe, M., et al. 1995. Science. 269: 1424-7. PMID: 7544915
- Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. | Régnier, CH., et al. 1995. J Biol Chem. 270: 25715-21. PMID: 7592751
- Contenders in FasL/TNF death signaling. | Cleveland, JL. and Ihle, JN. 1995. Cell. 81: 479-82. PMID: 7758103
- The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. | Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
- Transducers of life and death: TNF receptor superfamily and associated proteins. | Baker, SJ. and Reddy, EP. 1996. Oncogene. 12: 1-9. PMID: 8552378
- TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. | Cheng, G. and Baltimore, D. 1996. Genes Dev. 10: 963-73. PMID: 8608943
- Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand-dependent pathway. | McLellan, AD., et al. 1996. Eur J Immunol. 26: 1204-10. PMID: 8647193
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAF4 Antibody (B-9) | sc-390232 | 200 µg/ml | $322.00 | |||
TRAF4 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-530100 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRAF4 Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-523456 | 200 µg Ab, 40 µg BP | $361.00 | |||
TRAF4 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-543870 | 200 µg Ab; 20 µg BP | $361.00 | |||
TRAF4 Antibody (B-9) AC | sc-390232 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TRAF4 Antibody (B-9) HRP | sc-390232 HRP | 200 µg/ml | $322.00 | |||
TRAF4 Antibody (B-9) FITC | sc-390232 FITC | 200 µg/ml | $336.00 | |||
TRAF4 Antibody (B-9) PE | sc-390232 PE | 200 µg/ml | $349.00 | |||
TRAF4 Antibody (B-9) Alexa Fluor® 488 | sc-390232 AF488 | 200 µg/ml | $364.00 | |||
TRAF4 Antibody (B-9) Alexa Fluor® 546 | sc-390232 AF546 | 200 µg/ml | $364.00 | |||
TRAF4 Antibody (B-9) Alexa Fluor® 594 | sc-390232 AF594 | 200 µg/ml | $364.00 | |||
TRAF4 Antibody (B-9) Alexa Fluor® 647 | sc-390232 AF647 | 200 µg/ml | $364.00 | |||
TRAF4 Antibody (B-9) Alexa Fluor® 680 | sc-390232 AF680 | 200 µg/ml | $364.00 | |||
TRAF4 Antibody (B-9) Alexa Fluor® 790 | sc-390232 AF790 | 200 µg/ml | $364.00 |