TRAF3 Antibody (G-6): sc-6933

TRAF3 Antibody (G-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects TRAF3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TRAF3 monoclonal antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRAF3 protein plays a crucial role in the regulation of immune responses and cell signaling pathways, particularly in the context of tumor necrosis factor (TNF) receptor-mediated signaling. TRAF3 is primarily involved in the formation of signaling complexes that modulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, which are essential for the immune response and inflammation. Proper functioning of TRAF3 is vital, as dysregulation can lead to various diseases, including autoimmune disorders and cancer. TRAF3 interacts with other proteins in the TNF receptor superfamily, such as TRAF1 and TRAF2, to form heterodimeric complexes that enhance signaling efficiency. Identification of TRAF3′s role in these pathways underscores its importance in maintaining cellular homeostasis and responding to external stimuli, making TRAF3 monoclonal antibody (G-6) an invaluable tool for researchers studying immune signaling and related pathologies.

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TRAF3 Antibody (G-6) References:

1. Two TNF receptors.  |  Tartaglia, LA. and Goeddel, DV. 1992. Immunol Today. 13: 151-3. PMID: 1322675
2. TRAF3, ubiquitination, and B-lymphocyte regulation.  |  Lin, WW., et al. 2015. Immunol Rev. 266: 46-55. PMID: 26085206
3. TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation.  |  Bishop, GA., et al. 2018. Front Immunol. 9: 2161. PMID: 30319624
4. TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.  |  Zheng, W., et al. 2023. Signal Transduct Target Ther. 8: 79. PMID: 36823147
5. TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.  |  Li, Y., et al. 2023. J Exp Med. 220: PMID: 37097293
6. TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma.  |  Li, MY., et al. 2024. Proc Natl Acad Sci U S A. 121: e2320421121. PMID: 38662551
7. A novel RING finger protein interacts with the cytoplasmic domain of CD40.  |  Hu, HM., et al. 1994. J Biol Chem. 269: 30069-72. PMID: 7527023
8. Involvement of CRAF1, a relative of TRAF, in CD40 signaling.  |  Cheng, G., et al. 1995. Science. 267: 1494-8. PMID: 7533327
9. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.  |  Hsu, H., et al. 1995. Cell. 81: 495-504. PMID: 7758105
10. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.  |  Mosialos, G., et al. 1995. Cell. 80: 389-99. PMID: 7859281
11. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.  |  Rothe, M., et al. 1994. Cell. 78: 681-92. PMID: 8069916
12. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRAF3 Antibody (G-6) has 41 citations in a variety of scientific publications.

Primary antibodies like Anti-TRAF3 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRAF3 Antibody (G-6) Specifications

Alternate Product Name: TRAF3

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 322-444

Epitope Target: TRAF3

Epitope Species: human

Product Reactivity/Detection: TRAF3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 41 citations in various scientific publications

Available Conjugates/Forms for TRAF3 Antibody (G-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin