TR2 Antibody (D-4): sc-374049
- TR2 Antibody (D-4) is a mouse monoclonal IgG1 κ TR2 antibody provided at 200 µg/ml
- raised against amino acids 25-110 of TR2 of mouse origin
- TR2 Antibody (D-4) is recommended for detection of TR2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TR2 Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TR2 Antibody (D-4) for WB applications. These reagents are now offered in bundles with TR2 Antibody (D-4) (see ordering information below).
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TR2 Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects TR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TR2 (D-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TR2, an orphan receptor belonging to the steroid/thyroid hormone receptor superfamily, plays a crucial role in regulating essential biological processes such as growth, differentiation, and development. TR2 is involved in the transcriptional regulation of several key genes, including erythropoietin, which is vital for red blood cell production, and the muscle-specific aldolase A gene, which is important for energy metabolism in muscle tissues. TR2 interacts with TR4, a related orphan receptor, to form heterodimers that are implicated in neurogenesis and germ cell development. TR2 expression is influenced by factors such as p53 and ionizing radiation, suggesting a potential role in linking stress responses to steroid receptor signaling pathways. This multifaceted involvement in gene regulation and cellular processes underscores TR2′s importance in both normal physiology and disease states, making anti-TR2 antibody (D-4) a valuable tool for researchers studying these critical biological functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TR2 Antibody (D-4) References:
- Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. | Chang, C., et al. 1994. Proc Natl Acad Sci U S A. 91: 6040-4. PMID: 8016112
- Suppression of the human erythropoietin gene expression by the TR2 orphan receptor, a member of the steroid receptor superfamily. | Lee, HJ., et al. 1996. J Biol Chem. 271: 10405-12. PMID: 8626614
- p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily. | Lin, DL. and Chang, C. 1996. J Biol Chem. 271: 14649-52. PMID: 8663350
- Identification of the human aldolase A gene as the first induced target for the TR2 orphan receptor, a member of the steroid hormone receptor superfamily. | Chang, C., et al. 1997. Biochem Biophys Res Commun. 235: 205-11. PMID: 9196064
- A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway. | Young, WJ., et al. 1998. J Biol Chem. 273: 20877-85. PMID: 9694834
- A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4. | Lee, CH., et al. 1998. J Biol Chem. 273: 25209-15. PMID: 9737983
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TR2 Antibody (D-4) | sc-374049 | 200 µg/ml | $322.00 | |||
TR2 Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-527431 | 200 µg Ab; 10 µg BP | $361.00 | |||
TR2 Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-532804 | 200 µg Ab; 20 µg BP | $361.00 | |||
TR2 Antibody (D-4) AC | sc-374049 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TR2 Antibody (D-4) HRP | sc-374049 HRP | 200 µg/ml | $322.00 | |||
TR2 Antibody (D-4) FITC | sc-374049 FITC | 200 µg/ml | $336.00 | |||
TR2 Antibody (D-4) PE | sc-374049 PE | 200 µg/ml | $349.00 | |||
TR2 Antibody (D-4) Alexa Fluor® 488 | sc-374049 AF488 | 200 µg/ml | $364.00 | |||
TR2 Antibody (D-4) Alexa Fluor® 546 | sc-374049 AF546 | 200 µg/ml | $364.00 | |||
TR2 Antibody (D-4) Alexa Fluor® 594 | sc-374049 AF594 | 200 µg/ml | $364.00 | |||
TR2 Antibody (D-4) Alexa Fluor® 647 | sc-374049 AF647 | 200 µg/ml | $364.00 | |||
TR2 Antibody (D-4) Alexa Fluor® 680 | sc-374049 AF680 | 200 µg/ml | $364.00 | |||
TR2 Antibody (D-4) Alexa Fluor® 790 | sc-374049 AF790 | 200 µg/ml | $364.00 |