TorsinA Antibody (D-7): sc-373915
- TorsinA Antibody (D-7) is a mouse monoclonal IgG2a κ TorsinA antibody provided at 200 µg/ml
- raised against amino acids 176-260 mapping within an internal region of TorsinA of human origin
- TorsinA Antibody (D-7) is recommended for detection of TorsinA of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TorsinA Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TorsinA Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with TorsinA Antibody (D-7) (see ordering information below).
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TorsinA Antibody (D-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects TorsinA of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TorsinA Antibody (D-7) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TorsinA, consisting of 332 amino acids, plays a crucial role in the central nervous system, where TorsinA is predominantly expressed in neurons across nearly all regions. Cytoplasmic distribution of TorsinA is essential for chaperone-like activities that facilitate the assembly, operation, and disassembly of protein complexes, which is vital for maintaining cellular homeostasis and neuronal communication. Notably, mutations in the DYT1 gene, which encodes TorsinA, are linked to early-onset torsion dystonia, a movement disorder characterized by involuntary muscle contractions that can significantly impact quality of life. Understanding TorsinA function and interactions is critical for elucidating the underlying mechanisms of this disorder and developing potential therapeutic strategies. The gene encoding TorsinA is located on human chromosome 9q34 and shares high homology with three other mammalian genes and a nematode gene, indicating evolutionary significance and potential functional redundancy within the cellular environment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TorsinA Antibody (D-7) References:
- Immunocytochemical characterization of torsin proteins in mouse brain. | Konakova, M. and Pulst, SM. 2001. Brain Res. 922: 1-8. PMID: 11730696
- TorsinA immunoreactivity in brains of patients with DYT1 and non-DYT1 dystonia. | Walker, RH., et al. 2002. Neurology. 58: 120-4. PMID: 11781416
- The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. | Ozelius, LJ., et al. 1997. Nat Genet. 17: 40-8. PMID: 9288096
- AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. | Neuwald, AF., et al. 1999. Genome Res. 9: 27-43. PMID: 9927482
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TorsinA Antibody (D-7) | sc-373915 | 200 µg/ml | $322.00 | |||
TorsinA Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-529607 | 200 µg Ab; 10 µg BP | $361.00 | |||
TorsinA Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-522553 | 200 µg Ab, 40 µg BP | $361.00 | |||
TorsinA Antibody (D-7): m-IgG2a BP-HRP Bundle | sc-547338 | 200 µg Ab; 10 µg BP | $361.00 | |||
TorsinA Antibody (D-7) AC | sc-373915 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TorsinA Antibody (D-7) HRP | sc-373915 HRP | 200 µg/ml | $322.00 | |||
TorsinA Antibody (D-7) FITC | sc-373915 FITC | 200 µg/ml | $336.00 | |||
TorsinA Antibody (D-7) PE | sc-373915 PE | 200 µg/ml | $349.00 | |||
TorsinA Antibody (D-7) Alexa Fluor® 488 | sc-373915 AF488 | 200 µg/ml | $364.00 | |||
TorsinA Antibody (D-7) Alexa Fluor® 546 | sc-373915 AF546 | 200 µg/ml | $364.00 | |||
TorsinA Antibody (D-7) Alexa Fluor® 594 | sc-373915 AF594 | 200 µg/ml | $364.00 | |||
TorsinA Antibody (D-7) Alexa Fluor® 647 | sc-373915 AF647 | 200 µg/ml | $364.00 | |||
TorsinA Antibody (D-7) Alexa Fluor® 680 | sc-373915 AF680 | 200 µg/ml | $364.00 | |||
TorsinA Antibody (D-7) Alexa Fluor® 790 | sc-373915 AF790 | 200 µg/ml | $364.00 |