Torsin3A Antibody (D-9): sc-398045
- Torsin3A Antibody (D-9) is a mouse monoclonal IgG1 κ Torsin3A antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 207-234 within an internal region of Torsin3A of human origin
- Torsin3A Antibody (D-9) is recommended for detection of Torsin3A isoforms 1, 2 and 3 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Torsin3A Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Torsin3A (D-9): sc-398045.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Torsin3A Antibody (D-9) for WB and IHC(P) applications. These reagents are now offered in bundles with Torsin3A Antibody (D-9) (see ordering information below).
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Torsin3A Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Torsin3A of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Torsin3A antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Torsin3A (TOR3A), also known as ATP-dependent interferon-responsive protein (ADIR), is a 397 amino acid protein belonging to the clpA/clpB family, which is crucial for proper cellular processes. Torsin3A is primarily localized in the cytoplasm and endoplasmic reticulum, with highest expression levels found in the stomach, lymph nodes, and salivary glands. Torsin3A presence in these tissues suggests a role in cellular stress responses and protein homeostasis, particularly under conditions that may disrupt normal cellular function. Torsin3A features a hydrophobic N-terminal sequence, an ATP binding domain, and eight putative phosphorylation sites, which are essential for activity and regulation. Highly homologous to TorsinA and TorsinB, Torsin3A is involved in the assembly and disassembly of protein complexes, enhancing cellular resilience to stress and facilitating specific proteolytic processes. Torsin3A is classified as an interferon-responsive gene, with expression significantly upregulated in response to type 1 interferons (IFN-α and IFN-β), leading to a 5 to 40-fold increase in mRNA levels. Three isoforms of Torsin3A arise from alternative splicing, with isoform 2 being uniquely expressed in the placenta, highlighting diverse functional roles across different tissues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Torsin3A Antibody (D-9) References:
- Distribution of the mRNAs encoding torsinA and torsinB in the normal adult human brain. | Augood, SJ., et al. 1999. Ann Neurol. 46: 761-9. PMID: 10553994
- Molecular cloning of ADIR, a novel interferon responsive gene encoding a protein related to the torsins. | Dron, M., et al. 2002. Genomics. 79: 315-25. PMID: 11863361
- Development and anatomic localization of torsinA. | Oberlin, SR., et al. 2004. Adv Neurol. 94: 61-5. PMID: 14509655
- MoxR AAA+ ATPases: a novel family of molecular chaperones? | Snider, J. and Houry, WA. 2006. J Struct Biol. 156: 200-9. PMID: 16677824
- Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. | Muraro, NI. and Moffat, KG. 2006. J Neurobiol. 66: 1338-53. PMID: 16967506
- Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene. | van Bergen, CA., et al. 2007. Blood. 109: 4089-96. PMID: 17234742
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Torsin3A Antibody (D-9) | sc-398045 | 200 µg/ml | $316.00 | |||
Torsin3A Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-530676 | 200 µg Ab; 10 µg BP | $354.00 | |||
Torsin3A Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-524196 | 200 µg Ab, 40 µg BP | $354.00 | |||
Torsin3A Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-544193 | 200 µg Ab; 20 µg BP | $354.00 | |||
Torsin3A Antibody (D-9) AC | sc-398045 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Torsin3A Antibody (D-9) HRP | sc-398045 HRP | 200 µg/ml | $316.00 | |||
Torsin3A Antibody (D-9) FITC | sc-398045 FITC | 200 µg/ml | $330.00 | |||
Torsin3A Antibody (D-9) PE | sc-398045 PE | 200 µg/ml | $343.00 | |||
Torsin3A Antibody (D-9) Alexa Fluor® 488 | sc-398045 AF488 | 200 µg/ml | $357.00 | |||
Torsin3A Antibody (D-9) Alexa Fluor® 546 | sc-398045 AF546 | 200 µg/ml | $357.00 | |||
Torsin3A Antibody (D-9) Alexa Fluor® 594 | sc-398045 AF594 | 200 µg/ml | $357.00 | |||
Torsin3A Antibody (D-9) Alexa Fluor® 647 | sc-398045 AF647 | 200 µg/ml | $357.00 | |||
Torsin3A Antibody (D-9) Alexa Fluor® 680 | sc-398045 AF680 | 200 µg/ml | $357.00 | |||
Torsin3A Antibody (D-9) Alexa Fluor® 790 | sc-398045 AF790 | 200 µg/ml | $357.00 | |||
Torsin3A (D-9) Neutralizing Peptide | sc-398045 P | 100 µg/0.5 ml | $68.00 |