TORC3 Antibody (A-12): sc-390712
- TORC3 Antibody (A-12) is a mouse monoclonal IgG1 κ TORC3 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 563-594 of TORC3 of human origin
- TORC3 Antibody (A-12) is recommended for detection of TORC3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-TORC3 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TORC3 Antibody (A-12) for WB applications. These reagents are now offered in bundles with TORC3 Antibody (A-12) (see ordering information below).
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TORC3 Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects TORC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TORC3 (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TORC3, also known as CRTC3 (CREB-regulated transcription coactivator 3), is a 619 amino acid protein that plays a crucial role in cellular signaling and gene expression regulation. TORC3 is primarily located in both the cytoplasm and nucleus, which enables interaction with various transcription factors and modulation of gene expression in response to cellular signals. TORC3 acts as a transcriptional coactivator for CREB-1, influencing the expression of genes activated by CREB, and is involved in the SIK/TORC signaling pathway, which is essential for processes such as energy metabolism and stress response. TORC3 is expressed in various tissues, including lung, colon, brain, ovary, kidney, prostate, and heart, and is particularly important in lymphocytes, where TORC3 contributes to immune responses. Multiple alternatively spliced isoforms of TORC3 further underscore functional diversity and regulatory potential in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TORC3 Antibody (A-12) References:
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. | Iourgenko, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 12147-52. PMID: 14506290
- TORCs: transducers of regulated CREB activity. | Conkright, MD., et al. 2003. Mol Cell. 12: 413-23. PMID: 14536081
- Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. | Koga, H., et al. 2004. J Biol Chem. 279: 52978-83. PMID: 15466468
- TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. | Siu, YT., et al. 2006. J Virol. 80: 7052-9. PMID: 16809310
- Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. | Wu, Z., et al. 2006. Proc Natl Acad Sci U S A. 103: 14379-84. PMID: 16980408
- BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3. | Hishiki, T., et al. 2007. J Biol Chem. 282: 28335-28343. PMID: 17644518
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TORC3 Antibody (A-12) | sc-390712 | 200 µg/ml | $316.00 | |||
TORC3 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-530237 | 200 µg Ab; 10 µg BP | $354.00 | |||
TORC3 Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-523648 | 200 µg Ab, 40 µg BP | $354.00 | |||
TORC3 Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-543946 | 200 µg Ab; 20 µg BP | $354.00 | |||
TORC3 Antibody (A-12) AC | sc-390712 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TORC3 Antibody (A-12) HRP | sc-390712 HRP | 200 µg/ml | $316.00 | |||
TORC3 Antibody (A-12) FITC | sc-390712 FITC | 200 µg/ml | $330.00 | |||
TORC3 Antibody (A-12) PE | sc-390712 PE | 200 µg/ml | $343.00 | |||
TORC3 Antibody (A-12) Alexa Fluor® 488 | sc-390712 AF488 | 200 µg/ml | $357.00 | |||
TORC3 Antibody (A-12) Alexa Fluor® 546 | sc-390712 AF546 | 200 µg/ml | $357.00 | |||
TORC3 Antibody (A-12) Alexa Fluor® 594 | sc-390712 AF594 | 200 µg/ml | $357.00 | |||
TORC3 Antibody (A-12) Alexa Fluor® 647 | sc-390712 AF647 | 200 µg/ml | $357.00 | |||
TORC3 Antibody (A-12) Alexa Fluor® 680 | sc-390712 AF680 | 200 µg/ml | $357.00 | |||
TORC3 Antibody (A-12) Alexa Fluor® 790 | sc-390712 AF790 | 200 µg/ml | $357.00 | |||
TORC3 (A-12) Neutralizing Peptide | sc-390712 P | 100 µg/0.5 ml | $68.00 |