TORC1 Antibody (A-1): sc-271333
- TORC1 Antibody (A-1) is a mouse monoclonal IgG2a κ TORC1 antibody provided at 200 µg/ml
- raised against amino acids 391-515 mapping within an internal region of TORC1 of human origin
- TORC1 Antibody (A-1) is recommended for detection of TORC1 of human origin by WB, IP, IF and ELISA
- Anti-TORC1 Antibody (A-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-271333 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TORC1 Antibody (A-1) for WB applications. These reagents are now offered in bundles with TORC1 Antibody (A-1) (see ordering information below).
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TORC1 Antibody (A-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects TORC1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TORC1 (A-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The TORC (transducer of regulated cAMP response element-binding) proteins, which include TORC1 and TORC2, play a crucial role as coactivators of the cAMP response element-binding protein (CREB), facilitating the transcription of genes in response to hormonal signals. TORC1 is primarily located in the nucleus, where TORC1 is essential for regulating gene expression linked to metabolic processes and neuronal function. Nuclear localization of TORC1 enables direct interaction with CREB, thereby influencing the transcription of target genes critical for cellular responses to cAMP signaling. Translocation of TORC proteins from the nucleus is a key step in activating CRE-mediated gene expression, highlighting TORC1′s importance in cellular signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TORC1 Antibody (A-1) References:
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. | Iourgenko, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 12147-52. PMID: 14506290
- TORCs: transducers of regulated CREB activity. | Conkright, MD., et al. 2003. Mol Cell. 12: 413-23. PMID: 14536081
- The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. | Screaton, RA., et al. 2004. Cell. 119: 61-74. PMID: 15454081
- Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. | Bittinger, MA., et al. 2004. Curr Biol. 14: 2156-61. PMID: 15589160
- Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. | El-Naggar, AK. 2006. Adv Anat Pathol. 13: 80-2. PMID: 16670462
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TORC1 Antibody (A-1) | sc-271333 | 200 µg/ml | $322.00 | |||
TORC1 Antibody (A-1): m-IgG Fc BP-HRP Bundle | sc-529165 | 200 µg Ab; 10 µg BP | $361.00 | |||
TORC1 Antibody (A-1): m-IgGκ BP-HRP Bundle | sc-521913 | 200 µg Ab, 40 µg BP | $361.00 | |||
TORC1 Antibody (A-1): m-IgG2a BP-HRP Bundle | sc-547271 | 200 µg Ab; 10 µg BP | $361.00 | |||
TORC1 Antibody (A-1) X | sc-271333 X | 200 µg/0.1 ml | $322.00 | |||
TORC1 Antibody (A-1) AC | sc-271333 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TORC1 Antibody (A-1) HRP | sc-271333 HRP | 200 µg/ml | $322.00 | |||
TORC1 Antibody (A-1) FITC | sc-271333 FITC | 200 µg/ml | $336.00 | |||
TORC1 Antibody (A-1) PE | sc-271333 PE | 200 µg/ml | $349.00 | |||
TORC1 Antibody (A-1) Alexa Fluor® 488 | sc-271333 AF488 | 200 µg/ml | $364.00 | |||
TORC1 Antibody (A-1) Alexa Fluor® 546 | sc-271333 AF546 | 200 µg/ml | $364.00 | |||
TORC1 Antibody (A-1) Alexa Fluor® 594 | sc-271333 AF594 | 200 µg/ml | $364.00 | |||
TORC1 Antibody (A-1) Alexa Fluor® 647 | sc-271333 AF647 | 200 µg/ml | $364.00 | |||
TORC1 Antibody (A-1) Alexa Fluor® 680 | sc-271333 AF680 | 200 µg/ml | $364.00 | |||
TORC1 Antibody (A-1) Alexa Fluor® 790 | sc-271333 AF790 | 200 µg/ml | $364.00 |