Tom6 Antibody (E-6): sc-514967

Tom6 Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tom6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Tom6 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tom6, also known as translocase of outer mitochondrial membrane 6 homolog (yeast) or OBTP, is a crucial component of the mitochondrial preprotein translocase complex located in the outer mitochondrial membrane. This 74 amino acid protein plays a vital role in the import of nuclear-encoded precursor proteins into mitochondria, which is essential for mitochondrial function and energy production. Tom6 helps maintain mitochondrial integrity and supports cellular metabolism by facilitating the translocation of proteins necessary for mitochondrial biogenesis and function. Tom6 is encoded by a gene located on human chromosome 6p25.3 and mouse chromosome 17 C, highlighting its evolutionary conservation and importance across species.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Tom6 Antibody (E-6) References:

1. Biogenesis of Tom40, core component of the TOM complex of mitochondria.  |  Rapaport, D. and Neupert, W. 1999. J Cell Biol. 146: 321-31. PMID: 10427088
2. The TOM core complex: the general protein import pore of the outer membrane of mitochondria.  |  Ahting, U., et al. 1999. J Cell Biol. 147: 959-68. PMID: 10579717
3. The transport machinery for the import of preproteins across the outer mitochondrial membrane.  |  Ryan, MT., et al. 2000. Int J Biochem Cell Biol. 32: 13-21. PMID: 10661891
4. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane.  |  Kato, H. and Mihara, K. 2008. Biochem Biophys Res Commun. 369: 958-63. PMID: 18331822
5. Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37.  |  Dukanovic, J., et al. 2009. Mol Cell Biol. 29: 5975-88. PMID: 19797086
6. Mitochondrial protein import. Tom40 plays a major role in targeting and translocation of preproteins by forming a specific binding site for the presequence.  |  Rapaport, D., et al. 1997. J Biol Chem. 272: 18725-31. PMID: 9228044
7. Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria.  |  Yano, M., et al. 1998. J Biol Chem. 273: 26844-51. PMID: 9756929
8. Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex.  |  Dekker, PJ., et al. 1998. Mol Cell Biol. 18: 6515-24. PMID: 9774667

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tom6 Antibody (E-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Tom6 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tom6 Antibody (E-6) Specifications

Alternate Product Name: Tom6

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-74

Epitope Target: Tom6

Epitope Species: human

Product Reactivity/Detection: Tom6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Tom6 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin