TNF-R1 Antibody (E-11): sc-374186
- TNF-R1 Antibody (E-11) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 427-454 at the C-terminus of TNF-R1 of mouse origin
- recommended for detection of TNF-R1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See TNF-R1 (H-5): sc-8436 for TNF-R1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TNF-R1 Antibody (E-11) for WB and IHC(P) applications. These reagents are now offered in bundles with TNF-R1 Antibody (E-11) (see ordering information below).
TNF-R1 Antibody (E-11) is a mouse monoclonal IgG2b antibody that detects TNF-R1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TNF-R1, a critical component of the immune response, is primarily located on the surface of most cell types, where TNF-R1 plays a pivotal role in mediating the effects of tumor necrosis factor, a key cytokine involved in inflammation and apoptosis. TNF-R1′s presence on diverse cell types allows for a wide range of biological responses, including cell survival, proliferation, and differentiation, making TNF-R1 essential for maintaining immune homeostasis. TNF-R1 interacts with several signaling proteins, including TRADD, FADD, and RIP, which are crucial for propagating apoptotic signals within the cell. TNF-R1′s ability to initiate apoptosis through its "death domain" motif underscores TNF-R1′s significance in regulating cell fate and highlights TNF-R1′s potential as a therapeutic target in diseases characterized by dysregulated apoptosis, such as cancer and autoimmune disorders. Anti-TNF-R1 antibody (E-11) is an invaluable tool for researchers investigating the complex roles of TNF signaling in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNF-R1 Antibody (E-11) | sc-374186 | 200 µg/ml | $316.00 | |||
TNF-R1 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-535408 | 200 µg Ab; 40 µg BP | $354.00 | |||
TNF-R1 Antibody (E-11): m-IgG2b BP-HRP Bundle | sc-549409 | 200 µg Ab; 10 µg BP | $354.00 | |||
TNF-R1 (E-11) Neutralizing Peptide | sc-374186 P | 100 µg/0.5 ml | $68.00 |