TNAP Antibody (B4-78): sc-81754
- TNAP Antibody (B4-78) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against HSB cells of human origin
- recommended for detection of TNAP of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TNAP Antibody (B4-78). This work is in progress.
QUICK LINKS
SEE ALSO...
TNAP Antibody (B4-78) is a mouse monoclonal IgG1 antibody that detects tissue non-specific alkaline phosphatase (TNAP) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). TNAP is a crucial enzyme that plays a significant role in bone mineralization, functioning alongside plasma cell membrane glycoprotein-1 to facilitate mineral deposition in the bone matrix. This process is vital for maintaining healthy bone structure and density, and any disruption can lead to serious conditions such as hypophosphatasia, a rare genetic disorder characterized by impaired bone mineralization and skeletal defects. TNAP is widely expressed in tissues such as the liver, kidney, and bone, highlighting its importance in various physiological processes. The human gene encoding TNAP is located on chromosome 1p36.12, and understanding TNAP function and regulation is essential for elucidating mechanisms underlying bone health and disease. Anti-TNAP antibody (B4-78) serves as an invaluable tool for researchers investigating the role of alkaline phosphatases in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TNAP Antibody (B4-78) References:
- Rediscovering TNAP in the Brain: A Major Role in Regulating the Function and Development of the Cerebral Cortex. | Fonta, C., et al. 2015. Subcell Biochem. 76: 85-106. PMID: 26219708
- Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain. | Deracinois, B., et al. 2015. Subcell Biochem. 76: 125-51. PMID: 26219710
- TNAP, an Essential Player in Membrane Lipid Rafts of Neuronal Cells. | Ermonval, M., et al. 2015. Subcell Biochem. 76: 167-83. PMID: 26219712
- TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders. | Diaz-Hernandez, M., et al. 2015. Subcell Biochem. 76: 375-85. PMID: 26219721
- TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism. | Graser, S., et al. 2021. Int J Mol Sci. 22: PMID: 33477631
- TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways. | Cheng, X., et al. 2021. EBioMedicine. 67: 103370. PMID: 33971401
- TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy. | Sebastián-Serrano, Á., et al. 2022. Neurobiol Dis. 165: 105632. PMID: 35065251
- NPP1 and TNAP hydrolyze ATP synergistically during biomineralization. | Andrilli, LHS., et al. 2023. Purinergic Signal. 19: 353-366. PMID: 35870033
- Apigenin Modulates AnxA6- and TNAP-Mediated Osteoblast Mineralization. | Mroczek, J., et al. 2022. Int J Mol Sci. 23: PMID: 36361965
- Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway. | Zhang, H., et al. 2023. Chin Med J (Engl). 136: 1468-1477. PMID: 37192015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNAP Antibody (B4-78) | sc-81754 | 200 µg/ml | $322.00 | |||
TNAP Antibody (B4-78) FITC | sc-81754 FITC | 200 µg/ml | $336.00 | |||
TNAP Antibody (B4-78) PE | sc-81754 PE | 200 µg/ml | $349.00 |