TMTC3 Antibody (G-9): sc-398137
- TMTC3 Antibody (G-9) is a mouse monoclonal IgG2a κ TMTC3 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 892-915 at the C-terminus of TMTC3 of human origin
- TMTC3 Antibody (G-9) is recommended for detection of TMTC3 of mouse, rat, human and avian origin by WB, IP, IF and ELISA
- Anti-TMTC3 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TMTC3 Antibody (G-9). This work is in progress.
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TMTC3 Antibody (G-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects TMTC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMTC3 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMTC3 protein, also known as SMILE, is a 915 amino acid multi-pass membrane protein that belongs to the TMTC family and features ten tetratricopeptide repeat (TPR) motifs, which are critical for mediating protein-protein interactions. These TPR motifs consist of a degenerate 34 amino acid sequence that can form up to 16 tandem repeats, each adopting a helix-turn-helix structure that stacks with other TPR repeats to achieve specific ligand binding. The presence of these motifs is essential for TMTC3′s role in various cellular pathways, as TPR motifs facilitate the assembly of protein complexes vital for cellular signaling and function. TMTC3 is encoded by a gene located on human chromosome 12q21.32, which contains over 1,100 genes within 132 million bases, representing approximately 4.5% of the human genome. Anti-TMTC3 antibody (G-9) serves as an invaluable tool for researchers studying TMTC3′s intricate roles in cellular processes and potential implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMTC3 Antibody (G-9) References:
- Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. | Cortajarena, AL., et al. 2004. Protein Eng Des Sel. 17: 399-409. PMID: 15166314
- Molecular recognition via coupled folding and binding in a TPR domain. | Cliff, MJ., et al. 2005. J Mol Biol. 346: 717-32. PMID: 15713458
- Ligand binding by TPR domains. | Cortajarena, AL. and Regan, L. 2006. Protein Sci. 15: 1193-8. PMID: 16641492
- TPRpred: a tool for prediction of TPR-, PPR- and SEL1-like repeats from protein sequences. | Karpenahalli, MR., et al. 2007. BMC Bioinformatics. 8: 2. PMID: 17199898
- Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins. | Kajander, T., et al. 2007. Acta Crystallogr D Biol Crystallogr. 63: 800-11. PMID: 17582171
- Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. | Pál, M., et al. 2007. J Cell Sci. 120: 3238-48. PMID: 17878237
- TPR repeats and ELTR pattern: length variation as a function evolution mechanism. | Yang, KQ. 2007. Wei Sheng Wu Xue Bao. 47: 956-62. PMID: 18271245
- Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. | Young, JC., et al. 1998. J Biol Chem. 273: 18007-10. PMID: 9660753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMTC3 Antibody (G-9) | sc-398137 | 200 µg/ml | $322.00 | |||
TMTC3 Antibody (G-9) AC | sc-398137 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TMTC3 Antibody (G-9) HRP | sc-398137 HRP | 200 µg/ml | $322.00 | |||
TMTC3 Antibody (G-9) FITC | sc-398137 FITC | 200 µg/ml | $336.00 | |||
TMTC3 Antibody (G-9) PE | sc-398137 PE | 200 µg/ml | $349.00 | |||
TMTC3 Antibody (G-9) Alexa Fluor® 488 | sc-398137 AF488 | 200 µg/ml | $364.00 | |||
TMTC3 Antibody (G-9) Alexa Fluor® 546 | sc-398137 AF546 | 200 µg/ml | $364.00 | |||
TMTC3 Antibody (G-9) Alexa Fluor® 594 | sc-398137 AF594 | 200 µg/ml | $364.00 | |||
TMTC3 Antibody (G-9) Alexa Fluor® 647 | sc-398137 AF647 | 200 µg/ml | $364.00 | |||
TMTC3 Antibody (G-9) Alexa Fluor® 680 | sc-398137 AF680 | 200 µg/ml | $364.00 | |||
TMTC3 Antibody (G-9) Alexa Fluor® 790 | sc-398137 AF790 | 200 µg/ml | $364.00 | |||
TMTC3 (G-9) Neutralizing Peptide | sc-398137 P | 100 µg/0.5 ml | $69.00 |