TMPRSS2 Antibody (H-4): sc-515727

TMPRSS2 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMPRSS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TMPRSS2 antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMPRSS2, a 492 amino acid multimeric serine protease, plays a crucial role in regulating extracellular matrix components, which is vital for processes such as tumor growth and metastasis. TMPRSS2 (H-4) antibody detects protein predominantly expressed in prostate and kidney of mice, as well as in human small intestine, prostate, colon, stomach, and salivary gland. TMPRSS2 features several important structural domains, including a serine protease domain of S1 family, a scavenger receptor cysteine-rich domain, an LDL receptor class A domain, and a transmembrane domain, which collectively contribute to enzymatic activity and functional versatility. TMPRSS2 exists in both full-length form and cleaved protease domain, with expression upregulated by androgenic hormones, indicating potential involvement in prostate carcinogenesis. Anti-TMPRSS2 antibody (H-4) helps researchers study TMPRSS2′s interactions with various growth factors and activation mechanisms, highlighting significance in both normal physiological processes and pathological conditions.

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TMPRSS2 Antibody (H-4) References:

1. Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.  |  Lin, B., et al. 1999. Cancer Res. 59: 4180-4. PMID: 10485450
2. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues.  |  Vaarala, MH., et al. 2001. J Pathol. 193: 134-40. PMID: 11169526
3. Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.  |  Afar, DE., et al. 2001. Cancer Res. 61: 1686-92. PMID: 11245484
4. Expression profiling reveals hepsin overexpression in prostate cancer.  |  Magee, JA., et al. 2001. Cancer Res. 61: 5692-6. PMID: 11479199
5. Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint.  |  Kaur, T., et al. 2021. Virus Res. 294: 198275. PMID: 33359190
6. The discovery and development of transmembrane serine protease 2 (TMPRSS2) inhibitors as candidate drugs for the treatment of COVID-19.  |  Mantzourani, C., et al. 2022. Expert Opin Drug Discov. 17: 231-246. PMID: 35072549
7. ACE2 and TMPRSS2 Immunolocalization and COVID-19-Related Thyroid Disorder.  |  Park, GC., et al. 2022. Biology (Basel). 11: PMID: 35625425
8. Blockade of TMPRSS2-mediated priming of SARS-CoV-2 by lactoferricin.  |  Ohradanova-Repic, A., et al. 2022. Front Immunol. 13: 958581. PMID: 36081512
9. Would the Development of a Multitarget Inhibitor of 3CLpro and TMPRSS2 be Promising in the Fight Against SARS-CoV-2?  |  Dos Santos Nascimento, IJ. and de Moura, RO. 2023. Med Chem. 19: 405-412. PMID: 36221875
10. Human coronavirus HKU1 recognition of the TMPRSS2 host receptor.  |  McCallum, M., et al. 2024. Cell. 187: 4231-4245.e13. PMID: 38964328
11. Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.  |  Tanimoto, H., et al. 1997. Cancer Res. 57: 2884-7. PMID: 9230195
12. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.  |  Paoloni-Giacobino, A., et al. 1997. Genomics. 44: 309-20. PMID: 9325052

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TMPRSS2 Antibody (H-4) has 74 citations in a variety of scientific publications.

Primary antibodies like Anti-TMPRSS2 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TMPRSS2 Antibody (H-4) Specifications

Alternate Product Name: TMPRSS2

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 296-345

Epitope Target: TMPRSS2

Epitope Species: human

Product Reactivity/Detection: TMPRSS2 catalytic chain

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 74 citations in various scientific publications

Available Conjugates/Forms for TMPRSS2 Antibody (H-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin