TMEM43 Antibody (E-1): sc-365298

TMEM43 Antibody (E-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects TMEM43 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TMEM43 antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEM43, also known as transmembrane protein 43, LUMA, ARVC5, or ARVD5, is a 400 amino acid multi-pass membrane protein primarily localized to the inner nuclear membrane and endoplasmic reticulum. This localization plays a significant role in maintaining nuclear envelope structural integrity and is essential for emerin retention at the nuclear membrane. TMEM43 function is vital for cardiac health, as gene defects are linked to familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), a serious inherited condition characterized by heart failure, ventricular tachycardia, and increased risk of sudden cardiac death. TMEM43 (E-1) antibody enables valuable research insights into cellular processes and cardiac disease implications.

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TMEM43 Antibody (E-1) References:

1. Arrhythmogenic right ventricular cardiomyopathy: perspectives on disease.  |  Norman, MW. and McKenna, WJ. 1999. Z Kardiol. 88: 550-4. PMID: 10506390
2. The locus of a novel gene responsible for arrhythmogenic right-ventricular dysplasia characterized by early onset and high penetrance maps to chromosome 10p12-p14.  |  Li, D., et al. 2000. Am J Hum Genet. 66: 148-56. PMID: 10631146
3. Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane.  |  Dreger, M., et al. 2001. Proc Natl Acad Sci U S A. 98: 11943-8. PMID: 11593002
4. LUMA interacts with emerin and influences its distribution at the inner nuclear membrane.  |  Bengtsson, L. and Otto, H. 2008. J Cell Sci. 121: 536-48. PMID: 18230648
5. Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene.  |  Merner, ND., et al. 2008. Am J Hum Genet. 82: 809-21. PMID: 18313022
6. TMEM43 mutations associated with arrhythmogenic right ventricular cardiomyopathy in non-Newfoundland populations.  |  Baskin, B., et al. 2013. Hum Genet. 132: 1245-52. PMID: 23812740
7. Exercise and arrhythmic risk in TMEM43 p.S358L arrhythmogenic right ventricular cardiomyopathy.  |  Paulin, FL., et al. 2020. Heart Rhythm. 17: 1159-1166. PMID: 32120009
8. A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder.  |  Jang, MW., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34050020
9. Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.  |  Takemoto, Y., et al. 2021. Angew Chem Int Ed Engl. 60: 21824-21831. PMID: 34374184
10. Correction: TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis.  |  Li, J., et al. 2023. Cell Mol Biol Lett. 28: 3. PMID: 36653755
11. Generation of a TMEM43 knockout human induced pluripotent stem cell line (HDZi003-A-1) using CRISPR/Cas9.  |  Ratnavadivel, S., et al. 2024. Stem Cell Res. 76: 103354. PMID: 38430734
12. Localization of a gene responsible for arrhythmogenic right ventricular dysplasia to chromosome 3p23.  |  Ahmad, F., et al. Circulation. 98: 2791-5. PMID: 9860777

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TMEM43 Antibody (E-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TMEM43 Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TMEM43 Antibody (E-1) Specifications

Alternate Product Name: TMEM43

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 13-37

Epitope Target: TMEM43

Epitope Species: human

Product Reactivity/Detection: TMEM43

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TMEM43 Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin