TMEM38A Antibody (G-12): sc-390054

TMEM38A Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMEM38A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TMEM38A antibody (G-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEM38A, also known as trimeric intracellular cation channel type A, is a 299 amino acid multi-pass membrane protein that plays a crucial role in cellular calcium signaling. TMEM38A forms a homotrimeric protein with a unique ion-conducting pore, where the second transmembrane domain crosses only half of the lipid bilayer and loops back into the cytosol, essential for function. This structural arrangement allows TMEM38A to act as a monovalent cation channel, facilitating rapid intracellular calcium release maintenance, vital for various cellular processes, including muscle contraction and neurotransmitter release. TMEM38A gene is located on human chromosome 19p13.11 and spans approximately 27,893 bases, highlighting evolutionary significance and potential implications in calcium-related disorders.

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TMEM38A Antibody (G-12) References:

1. TRIC channels are essential for Ca2+ handling in intracellular stores.  |  Yazawa, M., et al. 2007. Nature. 448: 78-82. PMID: 17611541
2. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.  |  Yamazaki, D., et al. 2009. Pharmacol Ther. 121: 265-72. PMID: 19095005
3. Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation.  |  Yamazaki, D., et al. 2009. Development. 136: 2355-61. PMID: 19515693
4. Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.  |  Zhao, X., et al. 2010. J Biol Chem. 285: 37370-6. PMID: 20858894
5. Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations.  |  Wilkie, GS., et al. 2011. Mol Cell Proteomics. 10: M110.003129. PMID: 20876400
6. TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance.  |  Yamazaki, D., et al. 2011. Cell Metab. 14: 231-41. PMID: 21803293

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TMEM38A Antibody (G-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TMEM38A Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TMEM38A Antibody (G-12) Specifications

Alternate Product Name: TMEM38A

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 221-253

Epitope Target: TMEM38A

Epitope Species: human

Product Reactivity/Detection: TMEM38A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TMEM38A Antibody (G-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin