TMEM116 Antibody (B-3): sc-515375
- TMEM116 Antibody (B-3) is a mouse monoclonal IgG2b κ TMEM116 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 199-221 near the C-terminus of TMEM116 of human origin
- TMEM116 Antibody (B-3) is recommended for detection of TMEM116 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TMEM116 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMEM116 Antibody (B-3) for WB applications. These reagents are now offered in bundles with TMEM116 Antibody (B-3) (see ordering information below).
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SEE ALSO...
TMEM116 Antibody (B-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects TMEM116 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMEM116 (B-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEM116 protein, consisting of 228 amino acids, plays a critical role in cellular processes, particularly in membrane trafficking regulation and cellular homeostasis maintenance. TMEM116 function is essential for normal cellular pathways, and TMEM116 dysregulation has been implicated in various diseases, including skeletal deformities and developmental disorders. TMEM116 gene is located on human chromosome 12, which harbors over 1,100 genes and is associated with several genetic conditions, such as Noonan syndrome and various skeletal dysplasias. Understanding TMEM116 function and cellular interactions is vital for elucidating these disorders′ underlying mechanisms and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMEM116 Antibody (B-3) References:
- The genomic context of natural killer receptor extended gene families. | Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
- Genotype/phenotype analysis in a patient with pure and complete trisomy 12p. | Zumkeller, W., et al. 2004. Am J Med Genet A. 129A: 261-4. PMID: 15326625
- The phenotypic spectrum of COL2A1 mutations. | Nishimura, G., et al. 2005. Hum Mutat. 26: 36-43. PMID: 15895462
- Comparative genomics of natural killer cell receptor gene clusters. | Kelley, J., et al. 2005. PLoS Genet. 1: 129-39. PMID: 16132082
- The natural history of trisomy 12p. | Segel, R., et al. 2006. Am J Med Genet A. 140: 695-703. PMID: 16502429
- Noonan syndrome. | van der Burgt, I. 2007. Orphanet J Rare Dis. 2: 4. PMID: 17222357
- Cytogenetic and molecular analysis in trisomy 12p. | Allen, TL., et al. 1996. Am J Med Genet. 63: 250-6. PMID: 8723118
- Low basal transcripts of the COL2A1 collagen gene from lymphoblasts show alternative splicing of exon 12 in the Kniest form of spondyloepiphyseal dysplasia. | Yang, W. and Cole, WG. 1998. Hum Mutat. Suppl 1: S1-2. PMID: 9452022
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMEM116 Antibody (B-3) | sc-515375 | 200 µg/ml | $316.00 | |||
TMEM116 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-525014 | 200 µg Ab, 40 µg BP | $354.00 | |||
TMEM116 Antibody (B-3): m-IgG2b BP-HRP Bundle | sc-549206 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMEM116 Antibody (B-3) AC | sc-515375 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TMEM116 Antibody (B-3) HRP | sc-515375 HRP | 200 µg/ml | $316.00 | |||
TMEM116 Antibody (B-3) FITC | sc-515375 FITC | 200 µg/ml | $330.00 | |||
TMEM116 Antibody (B-3) PE | sc-515375 PE | 200 µg/ml | $343.00 | |||
TMEM116 Antibody (B-3) Alexa Fluor® 488 | sc-515375 AF488 | 200 µg/ml | $357.00 | |||
TMEM116 Antibody (B-3) Alexa Fluor® 546 | sc-515375 AF546 | 200 µg/ml | $357.00 | |||
TMEM116 Antibody (B-3) Alexa Fluor® 594 | sc-515375 AF594 | 200 µg/ml | $357.00 | |||
TMEM116 Antibody (B-3) Alexa Fluor® 647 | sc-515375 AF647 | 200 µg/ml | $357.00 | |||
TMEM116 Antibody (B-3) Alexa Fluor® 680 | sc-515375 AF680 | 200 µg/ml | $357.00 | |||
TMEM116 Antibody (B-3) Alexa Fluor® 790 | sc-515375 AF790 | 200 µg/ml | $357.00 | |||
TMEM116 (B-3) Neutralizing Peptide | sc-515375 P | 100 µg/0.5 ml | $68.00 |