TMEFF2 Antibody (J4B6): sc-135812
- TMEFF2 Antibody (J4B6) is a mouse monoclonal IgG2b provided at 50 µg/0.5 ml
- raised against a recombinant protein corresponding to amino acids 41-150 of TMEFF2 of human origin
- recommended for detection of TMEFF2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TMEFF2 Antibody (J4B6). This work is in progress.
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TMEFF2 Antibody (J4B6) is a mouse monoclonal IgG2b antibody that detects TMEFF2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TMEFF2, also known as hyperplastic polyposis protein 1 (HPP1) or tomoregulin (TR), is a single-pass type 1 membrane protein characterized by one epidermal growth factor (EGF)-like domain and two follistatin-like domains, playing a crucial role as a survival factor for mesencephalic and hippocampal neurons. TMEFF2 expression is notably high in the brain, prostate, and spinal cord, with additional presence in the colon and stromal cells of normal colonic mucosa, highlighting its importance in neural and reproductive health. TMEFF2 is highly glycosylated, which is significant as glycosylation can influence protein stability, localization, and interactions with other molecules, thereby affecting cellular signaling pathways. TMEFF2 is down-regulated in various tumor cell lines due to methylation events in its 5′ region, suggesting a potential role in tumorigenesis and making TMEFF2 a valuable target for cancer research. Anti-TMEFF2 antibody (J4B6) is an essential tool for researchers investigating the functional implications of TMEFF2 in both normal physiology and disease contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMEFF2 Antibody (J4B6) | sc-135812 | 50 µg/0.5 ml | $322.00 |