TMED2 Antibody (C-8): sc-376459
- TMED2 Antibody (C-8) is a mouse monoclonal IgG2b κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 94-201 mapping at the C-terminus of TMED2 of human origin
- recommended for detection of TMED2 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG2b BP-HRP is the preferred secondary detection reagent for TMED2 Antibody (C-8) for WB applications. This reagent is now offered in a bundle with TMED2 Antibody (C-8) (see ordering information below).
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TMED2 Antibody (C-8) is a mouse monoclonal IgG2b antibody that detects TMED2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMED2, also known as transmembrane emp24 domain trafficking protein 2, is a 201 amino acid protein belonging to the EMP24/GP25L family, characterized by its single-pass type I membrane structure and a GOLD domain. The GOLD domain, which spans approximately 90 to 150 amino acids, is crucial for mediating protein-protein interactions and plays a significant role in the dynamics of the Golgi apparatus. This domain facilitates interactions with lipids, sterols, and fatty acids, as well as with RUN domains that connect to cytoskeletal filaments of membrane proteins. TMED2 inhibits the GTPase-activating activity of ARFGAP1, thereby contributing to the budding process of coatomer-coated and other types of vesicles. Additionally, TMED2 forms a complex with SURF-4 and TMP21, enabling cargo molecule binding and facilitating collection into budding vesicles, which is essential for intracellular transport and proper cellular function. Anti-TMED2 antibody (C-8) serves as an invaluable tool for researchers studying vesicular transport and protein trafficking in various biological contexts.
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TMED2 Antibody (C-8) References:
- Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2. | Hou, W., et al. 2017. PLoS One. 12: e0182995. PMID: 28797121
- TMED2 promotes epithelial ovarian cancer growth. | Shi-Peng, G., et al. 2017. Oncotarget. 8: 94151-94165. PMID: 29212217
- TMED2-ALK, a Novel ALK Fusion Gene Identified in a Patient With Lung Adenocarcinoma. | Mao, W., et al. 2020. J Thorac Oncol. 15: e37-e39. PMID: 32093858
- The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10. | Yang, X., et al. 2020. BMC Cancer. 20: 312. PMID: 32293333
- Circular RNA circ_0008305 aggravates hepatocellular carcinoma growth through binding to miR-186 and inducing TMED2. | Zhang, X., et al. 2022. J Cell Mol Med. 26: 1742-1753. PMID: 33210454
- Multi-Omics Analysis Identified TMED2 as a Shared Potential Biomarker in Six Subtypes of Human Cancer. | Sial, N., et al. 2021. Int J Gen Med. 14: 7025-7042. PMID: 34707394
- ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains. | Anwar, MU., et al. 2022. Dev Cell. 57: 2334-2346.e8. PMID: 36174556
- Screening of the novel immune-suppressive biomarkers of TMED family and whether knockdown of TMED2/3/4/9 inhibits cell migration and invasion in breast cancer. | Fang, Z., et al. 2022. Ann Transl Med. 10: 1280. PMID: 36618780
- Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7. | Holm, JEJ., et al. 2023. Traffic. 24: 508-521. PMID: 37491993
- TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway. | Liang, C., et al. 2023. Curr Med Sci. 43: 1023-1032. PMID: 37615927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMED2 Antibody (C-8) | sc-376459 | 200 µg/ml | $322.00 | |||
TMED2 Antibody (C-8): m-IgG2b BP-HRP Bundle | sc-548599 | 200 µg Ab; 10 µg BP | $361.00 |