TMED2 Antibody (A-8): sc-376033
- TMED2 Antibody (A-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 94-201 mapping at the C-terminal of TMED2 of human origin
- recommended for detection of TMED2 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TMED2 Antibody (A-8) for WB and IHC(P) applications. These reagents are now offered in bundles with TMED2 Antibody (A-8) (see ordering information below).
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TMED2 Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects TMED2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TMED2, also known as transmembrane emp24 domain trafficking protein 2, is a 201 amino acid protein belonging to the EMP24/GP25L family, characterized by its single-pass type I membrane structure and the presence of a GOLD domain. The GOLD domain, which spans approximately 90 to 150 amino acids, is crucial for mediating protein-protein interactions and plays a significant role in the dynamics of the Golgi apparatus. This domain facilitates interactions with lipids, sterols, and fatty acids, as well as with RUN domains that connect to cytoskeletal filaments of membrane proteins. TMED2 inhibits the GTPase-activating activity of ARFGAP1, thereby contributing to the budding process of coatomer-coated vesicles and other types of coated vesicles. Additionally, TMED2 forms a complex with SURF-4 and TMP21, enabling cargo molecule binding and facilitating collection into budding vesicles, which is essential for intracellular transport and proper cellular function. Anti-TMED2 antibody (A-8) serves as a valuable tool for researchers studying vesicular transport and protein trafficking in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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TMED2 Antibody (A-8) References:
- TMED2/p24β1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines. | Zakariyah, A., et al. 2012. Placenta. 33: 214-9. PMID: 22212250
- TMED2 promotes epithelial ovarian cancer growth. | Shi-Peng, G., et al. 2017. Oncotarget. 8: 94151-94165. PMID: 29212217
- TMED2/emp24 is required in both the chorion and the allantois for placental labyrinth layer development. | Hou, W. and Jerome-Majewska, LA. 2018. Dev Biol. 444: 20-32. PMID: 30236446
- TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking. | Sun, MS., et al. 2018. Cell Rep. 25: 3086-3098.e3. PMID: 30540941
- TMED2 binding restricts SMO to the ER and Golgi compartments. | Di Minin, G., et al. 2022. PLoS Biol. 20: e3001596. PMID: 35353806
- ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains. | Anwar, MU., et al. 2022. Dev Cell. 57: 2334-2346.e8. PMID: 36174556
- VIRMA facilitates intrahepatic cholangiocarcinoma progression through epigenetic augmentation of TMED2 and PARD3B mRNA stabilization. | Xu, H., et al. 2023. J Gastroenterol. 58: 925-944. PMID: 37391589
- TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway. | Liang, C., et al. 2023. Curr Med Sci. 43: 1023-1032. PMID: 37615927
- TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport. | Sun, C., et al. 2024. Int J Biol Macromol. 262: 130055. PMID: 38354922
- Study on the role and mechanism of TMED2 in oral squamous cell carcinoma. | Wu, X., et al. 2025. Int J Biol Macromol. 289: 138805. PMID: 39694382
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMED2 Antibody (A-8) | sc-376033 | 200 µg/ml | $322.00 | |||
TMED2 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-540500 | 200 µg Ab; 10 µg BP | $361.00 | |||
TMED2 Antibody (A-8): m-IgG1 BP-HRP Bundle | sc-542162 | 200 µg Ab; 20 µg BP | $361.00 |