TMED1 Antibody (F-9): sc-377321
- TMED1 Antibody (F-9) is a mouse monoclonal IgG1 κ TMED1 antibody provided at 200 µg/ml
- raised against amino acids 123-175 mapping within an internal region of TMED1 of human origin
- TMED1 Antibody (F-9) is recommended for detection of TMED1 of human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine and porcine
- Anti-TMED1 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMED1 Antibody (F-9) for WB and IHC(P) applications. These reagents are now offered in bundles with TMED1 Antibody (F-9) (see ordering information below).
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TMED1 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMED1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TMED1 (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMED1, also known as transmembrane emp24 protein transport domain containing 1, ST2L, Il1rl1l, or IL1RL1LG, is a 227 amino acid protein that belongs to the EMP24/GP25L family and is characterized by a single-pass type I membrane structure, which includes a GOLD domain. The GOLD domain, consisting of approximately 90 to 150 amino acids, is crucial for mediating protein-protein interactions and is involved in the dynamics of the Golgi apparatus. This domain facilitates interactions with lipid, sterol, or fatty acid domains, as well as with the RUN domain, which connects to cytoskeletal filaments, highlighting TMED1′s significant role in protein trafficking and cellular organization. The TMED1 gene is located on human chromosome 19, a region known for its high gene density, containing around 1,400 genes within over 63 million bases. Understanding the function and interactions of TMED1 is vital, as TMED1 plays a key role in the transport and processing of proteins, which are essential for maintaining cellular homeostasis and responding to various physiological stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMED1 Antibody (F-9) References:
- Identification of a lumenal sequence specifying the assembly of Emp24p into p24 complexes in the yeast secretory pathway. | Ciufo, LF. and Boyd, A. 2000. J Biol Chem. 275: 8382-8. PMID: 10722670
- RUN domains: a new family of domains involved in Ras-like GTPase signaling. | Callebaut, I., et al. 2001. Trends Biochem Sci. 26: 79-83. PMID: 11166556
- The GOLD domain, a novel protein module involved in Golgi function and secretion. | Anantharaman, V. and Aravind, L. 2002. Genome Biol. 3: research0023. PMID: 12049664
- Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. | Moodie, SJ., et al. 2002. Eur J Immunogenet. 29: 287-91. PMID: 12121272
- The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. | Schimmöller, F., et al. 1995. EMBO J. 14: 1329-39. PMID: 7729411
- gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. | Dominguez, M., et al. 1998. J Cell Biol. 140: 751-65. PMID: 9472029
- Identification of potential regulatory elements for the transport of Emp24p. | Nakamura, N., et al. 1998. Mol Biol Cell. 9: 3493-503. PMID: 9843583
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMED1 Antibody (F-9) | sc-377321 | 200 µg/ml | $322.00 | |||
TMED1 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-530007 | 200 µg Ab; 10 µg BP | $361.00 | |||
TMED1 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-523281 | 200 µg Ab, 40 µg BP | $361.00 | |||
TMED1 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-543814 | 200 µg Ab; 20 µg BP | $361.00 | |||
TMED1 Antibody (F-9) AC | sc-377321 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TMED1 Antibody (F-9) HRP | sc-377321 HRP | 200 µg/ml | $322.00 | |||
TMED1 Antibody (F-9) FITC | sc-377321 FITC | 200 µg/ml | $336.00 | |||
TMED1 Antibody (F-9) PE | sc-377321 PE | 200 µg/ml | $349.00 | |||
TMED1 Antibody (F-9) Alexa Fluor® 488 | sc-377321 AF488 | 200 µg/ml | $364.00 | |||
TMED1 Antibody (F-9) Alexa Fluor® 546 | sc-377321 AF546 | 200 µg/ml | $364.00 | |||
TMED1 Antibody (F-9) Alexa Fluor® 594 | sc-377321 AF594 | 200 µg/ml | $364.00 | |||
TMED1 Antibody (F-9) Alexa Fluor® 647 | sc-377321 AF647 | 200 µg/ml | $364.00 | |||
TMED1 Antibody (F-9) Alexa Fluor® 680 | sc-377321 AF680 | 200 µg/ml | $364.00 | |||
TMED1 Antibody (F-9) Alexa Fluor® 790 | sc-377321 AF790 | 200 µg/ml | $364.00 |