TLR9 Antibody (26C593): sc-52966

TLR9 Antibody (26C593) is a mouse monoclonal IgG1 kappa light chain antibody that detects TLR9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). TLR9 (26C593) antibody is available in a non-conjugated form, allowing for versatile applications in various experimental settings. TLR9 plays a crucial role in the innate immune system by recognizing specific unmethylated CpG motifs found in bacterial and viral DNA, which is essential for initiating an immune response. This recognition triggers the activation of signaling pathways that lead to the production of pro-inflammatory cytokines, thereby enhancing the host′s ability to combat infections. TLR9 is predominantly located in immune cells such as dendritic cells and B cells, particularly in the spleen, lymph nodes, and bone marrow, where TLR9 acts as a sentinel for pathogen detection. The strategic localization of TLR9 in these immune-rich tissues underscores TLR9′s importance in orchestrating the body′s defense mechanisms against pathogens. By utilizing anti-TLR9 antibody (26C593) in research, scientists can gain valuable insights into the immune response and the role of TLR9 in various diseases, including autoimmune disorders and infections.

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TLR9 Antibody (26C593) References:

1. TLR9 as a key receptor for the recognition of DNA.  |  Kumagai, Y., et al. 2008. Adv Drug Deliv Rev. 60: 795-804. PMID: 18262306
2. TLR9 signaling defines distinct prognostic subsets in CLL.  |  Efremov, DG., et al. 2013. Front Biosci (Landmark Ed). 18: 371-86. PMID: 23276930
3. TLR9 and its signaling pathway in multiple sclerosis.  |  Zhou, Y., et al. 2017. J Neurol Sci. 373: 95-99. PMID: 28131238
4. Role of TLR9 in Oncogenic Virus-Produced Cancer.  |  Martínez-Campos, C., et al. 2017. Viral Immunol. 30: 98-105. PMID: 28151089
5. TLR9-based immunotherapy for the treatment of allergic diseases.  |  Farrokhi, S., et al. 2017. Immunotherapy. 9: 339-346. PMID: 28303762
6. HSV-1/TLR9-Mediated IFNβ and TNFα Induction Is Mal-Dependent in Macrophages.  |  Zyzak, J., et al. 2020. J Innate Immun. 12: 387-398. PMID: 31851971
7. Development of CpG oligodeoxynucleotide TLR9 agonists in anti-cancer therapy.  |  Jin, Y., et al. 2021. Expert Rev Anticancer Ther. 21: 841-851. PMID: 33831324
8. TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging.  |  Albuquerque-Souza, E., et al. 2022. J Dent Res. 101: 1628-1636. PMID: 35918888
9. Characterization of cooperative PS-oligo activation of human TLR9.  |  Pollak, AJ., et al. 2023. Mol Ther Nucleic Acids. 33: 832-844. PMID: 37675184
10. TLR9 promotes monocytic myeloid-derived suppressor cell induction during JEV infection.  |  Lian, T., et al. 2024. Microbes Infect. 26: 105336. PMID: 38724001

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR9 Antibody (26C593) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR9 Antibody (26C593) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR9 Antibody (26C593) Specifications

Alternate Product Name: TLR9

Product Clone Name: 26C593

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 268-284

Epitope Target: TLR9

Epitope Species: human

Product Reactivity/Detection: TLR9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for TLR9 Antibody (26C593): N/A

The preferred TLR9 antibody is TLR9 Antibody (E-9): sc-518138.