TLR5 Antibody (H-11): sc-518106
- TLR5 Antibody (H-11) is a mouse monoclonal IgM κ TLR5 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 132-156 within an extracellular domain of TLR5 of human origin
- recommended for detection of TLR5 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TLR5 Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TLR5 Antibody (H-11) for WB applications. This reagent is now offered in a bundle with TLR5 Antibody (H-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
TLR5 Antibody (H-11) is a mouse monoclonal IgM antibody that detects TLR5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TLR5 (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TLR5 plays a crucial role in the innate immune response by recognizing bacterial flagellin, which is essential for the activation of immune signaling pathways that lead to the production of pro-inflammatory cytokines. This function is vital for the host′s defense against infections, as TLR5 helps to initiate a rapid immune response to microbial threats. TLR5 is predominantly expressed in the ovary and peripheral blood leukocytes, particularly in monocytes, and is also found in lower levels in the prostate and testis. The presence of TLR5 in these tissues underscores its importance in both reproductive health and immune surveillance, making anti-TLR5 antibody (H-11) a valuable tool for researchers studying immune responses and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TLR5 Antibody (H-11) References:
- Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. | Kumar Pachathundikandi, S., et al. 2011. PLoS One. 6: e19614. PMID: 21573018
- Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. | Xu, ZZ., et al. 2015. Nat Med. 21: 1326-31. PMID: 26479925
- Direct Regulation of TLR5 Expression by Caveolin-1. | Lim, JS., et al. 2015. Mol Cells. 38: 1111-7. PMID: 26615831
- Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis. | Lopetuso, LR., et al. 2017. Inflamm Bowel Dis. 23: 392-403. PMID: 28146004
- Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis. | Elloumi, N., et al. 2017. Clin Exp Immunol. 190: 328-339. PMID: 28763101
- Cyprinid-specific duplicated membrane TLR5 senses dsRNA as functional homodimeric receptors. | Liao, Z., et al. 2022. EMBO Rep. 23: e54281. PMID: 35678424
- TLR-5 ligand conjugated with Per a 10 and T cell peptides potentiates Treg/Th1 response through PI3K/mTOR axis. | Mishra, R., et al. 2022. Int Immunopharmacol. 113: 109389. PMID: 36332450
- Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food. | Kemter, AM., et al. 2023. Cell Rep. 42: 113153. PMID: 37742185
- Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner. | Zhao, J., et al. 2024. Cell Death Dis. 15: 120. PMID: 38331868
- TLR5 agonist in combination with anti-PD-1 treatment enhances anti-tumor effect through M1/M2 macrophage polarization shift and CD8+ T cell priming. | Lee, J., et al. 2024. Cancer Immunol Immunother. 73: 102. PMID: 38630304
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TLR5 Antibody (H-11) | sc-518106 | 200 µg/ml | $322.00 | |||
TLR5 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-525373 | 200 µg Ab, 40 µg BP | $361.00 | |||
TLR5 Antibody (H-11) AC | sc-518106 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TLR5 Antibody (H-11) HRP | sc-518106 HRP | 200 µg/ml | $322.00 | |||
TLR5 Antibody (H-11) FITC | sc-518106 FITC | 200 µg/ml | $336.00 | |||
TLR5 Antibody (H-11) PE | sc-518106 PE | 200 µg/ml | $349.00 | |||
TLR5 Antibody (H-11) Alexa Fluor® 488 | sc-518106 AF488 | 200 µg/ml | $364.00 | |||
TLR5 Antibody (H-11) Alexa Fluor® 546 | sc-518106 AF546 | 200 µg/ml | $364.00 | |||
TLR5 Antibody (H-11) Alexa Fluor® 594 | sc-518106 AF594 | 200 µg/ml | $364.00 | |||
TLR5 Antibody (H-11) Alexa Fluor® 647 | sc-518106 AF647 | 200 µg/ml | $364.00 | |||
TLR5 Antibody (H-11) Alexa Fluor® 680 | sc-518106 AF680 | 200 µg/ml | $364.00 | |||
TLR5 Antibody (H-11) Alexa Fluor® 790 | sc-518106 AF790 | 200 µg/ml | $364.00 |