TLR1 Antibody (GD2.F4): sc-80535

TLR1 Antibody (GD2.F4) is a mouse monoclonal IgG1 antibody that detects TLR1 in human samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). TLR1, a member of the Toll-like receptor (TLR) family, plays a crucial role in the innate immune response by recognizing pathogen-associated molecular patterns, which is essential for initiating inflammatory responses and activating adaptive immunity. Located primarily on the surface of immune cells such as macrophages and dendritic cells, TLR1 is integral to the detection of bacterial lipoproteins and other microbial components, leading to the activation of downstream signaling pathways, including the NFκB pathway. This activation is vital for the production of pro-inflammatory cytokines, which help orchestrate the immune response against infections. TLR1 is characterized by its type I transmembrane structure, featuring an extracellular domain rich in leucine repeats that facilitate ligand binding, and a cytoplasmic Toll/IL-1R-like domain that is crucial for signal transduction. TLR1′s ability to form heterodimers with TLR2 enhances its functional capacity, allowing for a broader recognition of diverse pathogens. With its significant role in immune surveillance and response, TLR1 serves as a key target for research into immune-related diseases and therapeutic interventions.

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TLR1 Antibody (GD2.F4) References:

1. TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages.  |  Pandey, SP., et al. 2015. Exp Parasitol. 154: 82-6. PMID: 25911242
2. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists.  |  Cheng, K., et al. 2015. Sci Adv. 1: PMID: 26101787
3. TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis.  |  Meyer, CG., et al. 2016. PLoS One. 11: e0156046. PMID: 27214039
4. C4b binding protein negatively regulates TLR1/2 response.  |  Morita, N., et al. 2017. Innate Immun. 23: 11-19. PMID: 27794068
5. Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization.  |  Hu, HG., et al. 2020. Chembiochem. 21: 1150-1154. PMID: 31702879
6. Toll-like receptors revisited; a possible role for TLR1 in lupus nephritis.  |  Yavuz, S., et al. 2021. Ann Rheum Dis. 80: 404-406. PMID: 32994161
7. Propionate induces cross-tolerance to TLR1/2 and TLR4 agonists in an IFIT-dependent manner.  |  Fischer, C., et al. 2022. Immunobiology. 227: 152186. PMID: 35131544
8. SIX1 attenuates inflammation and rheumatoid arthritis by silencing MyD88-dependent TLR1/2 signaling.  |  Zhan, H., et al. 2022. Int Immunopharmacol. 106: 108613. PMID: 35180623
9. C5AR1-induced TLR1/2 pathway activation drives proliferation and metastasis in anaplastic thyroid cancer.  |  Liu, B., et al. 2024. Mol Carcinog. 63: 1938-1952. PMID: 38934768
10. Inverse correlation between Leishmania-induced TLR1/2 and TGF-β differentially regulates parasite persistence in bone marrow during the chronic phase of infection.  |  Roy, K., et al. 2025. Cytokine. 185: 156811. PMID: 39612658

The preferred TLR1 antibody is TLR1 Antibody (H-8): sc-514399.