TKTL1/2 Antibody (E-8): sc-514513

TKTL1/2 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TKTL1 and TKTL2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TKTL1/2 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transketolase-like proteins, TKTL1 and TKTL2, play a pivotal role in cellular metabolism, particularly in the pentose phosphate pathway, which is essential for nucleotide synthesis and cellular redox balance. TKTL1, a 596 amino acid protein, is localized in both the nucleus and cytoplasm, and functions as a homodimer that requires calcium and thiamine pyrophosphate as cofactors to facilitate the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate into D-ribose 5-phosphate and D-xylulose 5-phosphate. This enzymatic activity is crucial for maintaining cellular function under varying metabolic conditions, especially in response to environmental changes. Notably, TKTL1 overexpression, which can exist in multiple alternatively spliced isoforms, has been linked to diabetic complications and the progression of epithelial tumors, highlighting its significance in both metabolic regulation and disease pathology. TKTL2, a 626 amino acid protein, also belongs to the Transketolase family and shares similar catalytic capabilities, further emphasizing the importance of these proteins in metabolic pathways.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TKTL1/2 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TKTL1/2 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TKTL1/2 Antibody (E-8) Specifications

Alternate Product Name: TKTL1/2

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 215-297

Epitope Target: TKTL1

Epitope Species: mouse

Product Reactivity/Detection: TKTL1 and TKTL2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TKTL1/2 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred TKTL1/2 antibody is TKTL1/2 Antibody (C-11): sc-271296.