TKTL1/2 Antibody (C-11): sc-271296

TKTL1/2 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TKTL1/2 by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TKTL1/2 (C-11) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TKTL1, also known as transketolase-like 1, plays a vital role in cellular metabolism by participating in the pentose phosphate pathway, which generates nucleotides and nucleic acids, supporting cell proliferation and survival. TKTL1 is localized in both nucleus and cytoplasm, coordinating metabolic processes in response to cellular demands. TKTL1 forms a homodimer and requires calcium and thiamine pyrophosphate as cofactors to catalyze the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate into D-ribose 5-phosphate and D-xylulose 5-phosphate. TKTL1 expression is significant in lung, brain, liver, heart, and kidney tissues, and elevated levels have been linked to diabetic complications and epithelial tumor progression. TKTL2, a closely related protein, shares functional similarities and catalyzes phosphate transfer reactions, highlighting the importance of transketolase family proteins in metabolic regulation.

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TKTL1/2 Antibody (C-11) References:

1. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer.  |  Coy, JF., et al. 2005. Clin Lab. 51: 257-73. PMID: 15991799
2. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted.  |  Langbein, S., et al. 2006. Br J Cancer. 94: 578-85. PMID: 16465194
3. Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer.  |  Staiger, WI., et al. 2006. Oncol Rep. 16: 657-61. PMID: 16969476
4. Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells.  |  Zhang, S., et al. 2007. Cancer Lett. 253: 108-14. PMID: 17321041
5. Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.  |  Völker, HU., et al. 2008. Am J Clin Pathol. 130: 50-7. PMID: 18550470
6. Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.  |  Kohrenhagen, N., et al. 2008. J Obstet Gynaecol Res. 34: 293-300. PMID: 18686341
7. Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals.  |  McCool, BA., et al. 1993. J Biol Chem. 268: 1397-404. PMID: 8419340
8. Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes.  |  Coy, JF., et al. 1996. Genomics. 32: 309-16. PMID: 8838793

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TKTL1/2 Antibody (C-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TKTL1/2 Antibody (C-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TKTL1/2 Antibody (C-11) Specifications

Alternate Product Name: TKTL1/2

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 231-288

Epitope Target: TKTL1

Epitope Species: human

Product Reactivity/Detection: TKTL1 and TKTL2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TKTL1/2 Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred TKTL1/2 antibody is TKTL1/2 Antibody (E-8): sc-514513.