TIMP-3 Antibody (B-2): sc-373839

TIMP-3 Antibody (B-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects TIMP-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TIMP-3 antibody (B-2) is available as a non-conjugated format. TIMP-3 protein plays a crucial role in regulating extracellular matrix remodeling and inhibits various metalloproteinases, including collagenases and gelatinases, which are involved in tissue degradation and repair processes. This inhibition maintains tissue integrity and prevents excessive matrix degradation, which can lead to pathological conditions such as fibrosis and cancer metastasis. TIMP-3 is unique among tissue inhibitors of metalloproteinases as the only member secreted and found in the nucleus, suggesting a potential role in regulating gene expression and cellular signaling pathways. TIMP-3 expression is particularly important in tissues undergoing remodeling, such as during wound healing and tumor progression, where TIMP-3 may influence cancer cell invasive potential.

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TIMP-3 Antibody (B-2) References:

1. Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.  |  Carmichael, DF., et al. 1986. Proc Natl Acad Sci U S A. 83: 2407-11. PMID: 3010309
2. Engineering of TIMP-3 as a LAP-fusion protein for targeting to sites of inflammation.  |  Alberts, BM., et al. 2019. J Cell Mol Med. 23: 1617-1621. PMID: 30450736
3. TIMP-3 as a therapeutic target for cancer.  |  Su, CW., et al. 2019. Ther Adv Med Oncol. 11: 1758835919864247. PMID: 31360238
4. The Diverse Roles of TIMP-3: Insights into Degenerative Diseases of the Senescent Retina and Brain.  |  Dewing, JM., et al. 2019. Cells. 9: PMID: 31877820
5. Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology.  |  Fan, D. and Kassiri, Z. 2020. Front Physiol. 11: 661. PMID: 32612540
6. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.  |  Docherty, AJ., et al. Nature. 318: 66-9. PMID: 3903517
7. The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.  |  Apte, SS., et al. 1995. J Biol Chem. 270: 14313-8. PMID: 7782289
8. Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10.  |  Apte, SS., et al. 1994. Dev Dyn. 200: 177-97. PMID: 7949367
9. Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family.  |  Silbiger, SM., et al. 1994. Gene. 141: 293-7. PMID: 8163205
10. Cloning and regulation of rat tissue inhibitor of metalloproteinases-2 in osteoblastic cells.  |  Cook, TF., et al. 1994. Arch Biochem Biophys. 311: 313-20. PMID: 8203893
11. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.  |  Greene, J., et al. 1996. J Biol Chem. 271: 30375-80. PMID: 8939999
12. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.  |  Gomez, DE., et al. 1997. Eur J Cell Biol. 74: 111-22. PMID: 9352216

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIMP-3 Antibody (B-2) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-TIMP-3 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIMP-3 Antibody (B-2) Specifications

Alternate Product Name: TIMP-3

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 181-210

Epitope Target: TIMP-3

Epitope Species: human

Product Reactivity/Detection: TIMP-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for TIMP-3 Antibody (B-2): P: Blocking Peptide