TIMMDC1 Antibody (G-10): sc-514927

TIMMDC1 Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIMMDC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIMMDC1 (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TIMMDC1 protein, also known as translocase of inner mitochondrial membrane domain-containing protein 1, Protein M5-14, or chromosome 3 open reading frame 1, is a 285 amino acid multi-pass membrane protein located in the inner mitochondrial membrane, where TIMMDC1 plays a crucial role in mitochondrial function. TIMMDC1 localization is vital as TIMMDC1 is involved in the assembly of the membrane arm of mitochondrial respiratory complex I, which is essential for coupling electron transfer to proton translocation, ultimately driving ATP production through ATP synthase as part of the electron transport chain. TIMMDC1 expression is significantly elevated in heart and skeletal muscle tissues, as well as in lung carcinoma cells, where TIMMDC1 depletion has been linked to reduced cell migration and proliferation, highlighting TIMMDC1′s potential role in cancer biology. TIMMDC1 gene is evolutionarily conserved across various species, including chimpanzees, Rhesus monkeys, dogs, cows, mice, rats, chickens, zebrafish, and Drosophila, underscoring TIMMDC1′s fundamental importance in cellular processes.

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TIMMDC1 Antibody (G-10) References:

1. Identification and expression analysis of C3orf1, a novel human gene homologous to the Drosophila RP140-upstream gene.  |  Escarceller, M., et al. 2000. DNA Seq. 11: 335-8. PMID: 11092749
2. Genome-wide conditional search for epistatic disease-predisposing variants in human association studies.  |  Wang, G., et al. 2010. Hum Hered. 70: 34-41. PMID: 20413980
3. Assembly factors for the membrane arm of human complex I.  |  Andrews, B., et al. 2013. Proc Natl Acad Sci U S A. 110: 18934-9. PMID: 24191001
4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.  |  Guarani, V., et al. 2014. Mol Cell Biol. 34: 847-61. PMID: 24344204
5. Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.  |  Wu, H., et al. 2014. Int J Mol Sci. 15: 20555-71. PMID: 25391042
6. Biallelic Mutations in TMEM126B Cause Severe Complex I Deficiency with a Variable Clinical Phenotype.  |  Alston, CL., et al. 2016. Am J Hum Genet. 99: 217-27. PMID: 27374774
7. Evolution of the Tim17 protein family.  |  Žárský, V. and Doležal, P. 2016. Biol Direct. 11: 54. PMID: 27760563
8. A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein-truncating variant.  |  Lake, NJ., et al. 2019. Hum Mutat. 40: 893-898. PMID: 30981218
9. miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.  |  Muys, BR., et al. 2019. Cancer Res. 79: 3294-3305. PMID: 31101765
10. Targeted resequencing reveals rare variants enrichment in multiple sclerosis susceptibility genes.  |  Gil-Varea, E., et al. 2020. Hum Mutat. 41: 1308-1320. PMID: 32196808
11. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis.  |  Murari, A., et al. 2021. iScience. 24: 102869. PMID: 34386730
12. Neuropathological hallmarks of antenatal mitochondrial diseases with a corpus callosum defect.  |  Boutaud, L., et al. 2023. Brain. 146: 1804-1811. PMID: 36349561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIMMDC1 Antibody (G-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TIMMDC1 Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIMMDC1 Antibody (G-10) Specifications

Alternate Product Name: TIMMDC1

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 7-285

Epitope Target: TIMMDC1

Epitope Species: human

Product Reactivity/Detection: TIMMDC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TIMMDC1 Antibody (G-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin