TIMMDC1 Antibody (F-1): sc-514926

TIMMDC1 Antibody (F-1) is a mouse monoclonal IgG2a antibody that detects TIMMDC1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIMMDC1, also known as Protein M5-14 or C3orf1, is a 285 amino acid multi-pass membrane protein located in the inner mitochondrial membrane, where TIMMDC1 plays a crucial role in the assembly and function of mitochondrial respiratory complex I. This complex is essential for cellular energy production, as complex I couples electron transfer to proton translocation, ultimately driving ATP synthesis via ATP synthase. TIMMDC1 depletion has been linked to impaired cell migration and proliferation in lung carcinoma cells, highlighting TIMMDC1′s potential role in cancer biology. Additionally, the TIMMDC1 gene is highly conserved across various species, including chimpanzees, Rhesus monkeys, dogs, cows, mice, rats, chickens, zebrafish, and Drosophila, indicating TIMMDC1′s fundamental importance in cellular processes. With TIMMDC1′s ability to facilitate the assembly of complex I, anti-TIMMDC1 antibody (F-1) serves as a valuable tool for researchers investigating mitochondrial function and its implications in health and disease.

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TIMMDC1 Antibody (F-1) References:

1. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.  |  Guarani, V., et al. 2014. Mol Cell Biol. 34: 847-61. PMID: 24344204
2. Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.  |  Wu, H., et al. 2014. Int J Mol Sci. 15: 20555-71. PMID: 25391042
3. Genetic diagnosis of Mendelian disorders via RNA sequencing.  |  Kremer, LS., et al. 2017. Nat Commun. 8: 15824. PMID: 28604674
4. TIMMDC1 Knockdown Inhibits Growth and Metastasis of Gastric Cancer Cells through Metabolic Inhibition and AKT/GSK3β/β-Catenin Signaling Pathway.  |  Liu, Y., et al. 2018. Int J Biol Sci. 14: 1256-1267. PMID: 30123074
5. Long non-coding RNA TCF7 contributes to the growth and migration of airway smooth muscle cells in asthma through targeting TIMMDC1/Akt axis.  |  Fan, M., et al. 2019. Biochem Biophys Res Commun. 508: 749-755. PMID: 30528236
6. Potentially Critical Roles of NDUFB5, TIMMDC1, and VDAC3 in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis.  |  Kang, K., et al. 2020. DNA Cell Biol. 39: 105-117. PMID: 31794266
7. Deep intronic TIMMDC1 variant delays diagnosis of rapidly progressive complex I deficiency.  |  Naber, M., et al. 2021. Eur J Med Genet. 64: 104120. PMID: 33278652
8. Oligonucleotide correction of an intronic TIMMDC1 variant in cells of patients with severe neurodegenerative disorder.  |  Kumar, R., et al. 2022. NPJ Genom Med. 7: 9. PMID: 35091571
9. New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation.  |  Li, Y., et al. 2024. Cell Mol Biol Lett. 29: 21. PMID: 38291374
10. Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.  |  Zhao, D., et al. 2024. JCI Insight. 9: PMID: 38652547

The preferred TIMMDC1 antibody is TIMMDC1 Antibody (G-10): sc-514927.