Tim17 Antibody (H-1): sc-271152
- Tim17 Antibody (H-1) is a mouse monoclonal IgG1 κ Tim17 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against a peptide mapping near the C-terminus of Tim17 of human origin
- Tim17 Antibody (H-1) is recommended for detection of Tim17 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine and canine
- Anti-Tim17 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Tim17 Antibody (H-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Tim17 Antibody (H-1) (see ordering information below).
Tim17 Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tim17 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Tim17 antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tim17 plays a crucial role in mitochondrial function, specifically in the translocation of nuclear-encoded preproteins into the mitochondrial matrix, which is essential for mitochondrial biogenesis and function. This process is facilitated by the translocases of the inner membrane (TIM), where Tim17, along with Tim23 and Tim44, forms a channel that allows the import of preproteins. Tim17 exists in two isoforms, Tim17a and Tim17b, which differ in their C-terminal sequences but are both vital for the structural integrity of the TIM complex. Proper functioning of Tim17 is critical, as any disruption in this translocation process can lead to mitochondrial dysfunction, which is implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. Using Tim17 (H-1) monoclonal antibody in your research can provide valuable insights into mitochondrial dynamics and the underlying mechanisms of diseases associated with mitochondrial dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tim17 Antibody (H-1) References:
- Genetic and structural characterization of the human mitochondrial inner membrane translocase. | Bauer, MF., et al. 1999. J Mol Biol. 289: 69-82. PMID: 10339406
- Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. | Brix, J., et al. 1999. J Biol Chem. 274: 16522-30. PMID: 10347216
- The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. | Moro, F., et al. 1999. EMBO J. 18: 3667-75. PMID: 10393182
- A multisubunit complex of outer and inner mitochondrial membrane protein translocases stabilized in vivo by translocation intermediates. | Schülke, N., et al. 1999. J Biol Chem. 274: 22847-54. PMID: 10428870
- The transport machinery for the import of preproteins across the outer mitochondrial membrane. | Ryan, MT., et al. 2000. Int J Biochem Cell Biol. 32: 13-21. PMID: 10661891
- Protein import into mitochondria. | Neupert, W. 1997. Annu Rev Biochem. 66: 863-917. PMID: 9242927
- Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria. | Yano, M., et al. 1998. J Biol Chem. 273: 26844-51. PMID: 9756929
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tim17 Antibody (H-1) | sc-271152 | 200 µg/ml | $316.00 | |||
Tim17 Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-529129 | 200 µg Ab; 10 µg BP | $354.00 | |||
Tim17 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-521861 | 200 µg Ab, 40 µg BP | $354.00 | |||
Tim17 Antibody (H-1): m-IgG1 BP-HRP Bundle | sc-543337 | 200 µg Ab; 20 µg BP | $354.00 | |||
Tim17 Antibody (H-1) AC | sc-271152 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Tim17 Antibody (H-1) HRP | sc-271152 HRP | 200 µg/ml | $316.00 | |||
Tim17 Antibody (H-1) FITC | sc-271152 FITC | 200 µg/ml | $330.00 | |||
Tim17 Antibody (H-1) PE | sc-271152 PE | 200 µg/ml | $343.00 | |||
Tim17 Antibody (H-1) Alexa Fluor® 488 | sc-271152 AF488 | 200 µg/ml | $357.00 | |||
Tim17 Antibody (H-1) Alexa Fluor® 546 | sc-271152 AF546 | 200 µg/ml | $357.00 | |||
Tim17 Antibody (H-1) Alexa Fluor® 594 | sc-271152 AF594 | 200 µg/ml | $357.00 | |||
Tim17 Antibody (H-1) Alexa Fluor® 647 | sc-271152 AF647 | 200 µg/ml | $357.00 | |||
Tim17 Antibody (H-1) Alexa Fluor® 680 | sc-271152 AF680 | 200 µg/ml | $357.00 | |||
Tim17 Antibody (H-1) Alexa Fluor® 790 | sc-271152 AF790 | 200 µg/ml | $357.00 | |||
Tim17 (H-1) Neutralizing Peptide | sc-271152 P | 100 µg/0.5 ml | $68.00 |