Thrombospondin 5 Antibody (F-7): sc-374660

Thrombospondin 5 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Thrombospondin 5 (THBS5) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-THBS5 antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. THBS5, also known as cartilage oligomeric matrix protein (COMP), plays a crucial role in cartilage and extracellular matrix structural integrity. THBS5 (F-7) monoclonal antibody targets a protein primarily found in cartilage, tendon, and vascular smooth muscle, where expression is developmentally regulated within chondrocyte territorial and interterritorial matrix. THBS5′s unique structure, including type 2 (epidermal growth factor-like) and type 3 (calmodulin-like) repeats, enables interactions with other extracellular matrix components, such as Collagen Types I, II, and IX, in a zinc-dependent manner. These interactions maintain cartilage mechanical properties and ensure proper tissue function. Mutations in the COMP/THBS5 gene are linked to genetic disorders like pseudoachondroplasia and multiple epiphyseal dysplasia, leading to skeletal abnormalities and early-onset osteoarthritis. Anti-THBS5 antibody (F-7)′s effective detection capabilities make this reagent invaluable for research into these conditions and cartilage biology.

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Thrombospondin 5 Antibody (F-7) References:

1. Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells.  |  Riessen, R., et al. 2001. Arterioscler Thromb Vasc Biol. 21: 47-54. PMID: 11145932
2. Pseudoachondroplasia and multiple epiphyseal dysplasia: mutation review, molecular interactions, and genotype to phenotype correlations.  |  Briggs, MD. and Chapman, KL. 2002. Hum Mutat. 19: 465-78. PMID: 11968079
3. Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.  |  Svensson, L., et al. 2002. Mol Cell Biol. 22: 4366-71. PMID: 12024046
4. Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs.  |  Dickinson, SC., et al. 2003. Matrix Biol. 22: 267-78. PMID: 12853037
5. Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.  |  Hedbom, E., et al. 1992. J Biol Chem. 267: 6132-6. PMID: 1556121
6. Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations.  |  Posey, KL., et al. 2008. Cell Mol Life Sci. 65: 687-99. PMID: 18193163
7. Cartilage oligomeric matrix protein/thrombospondin-5 (COMP/TSP-5) levels do not correlate to functional class in patients with rheumatoid arthritis.  |  Andrade, FD., et al. 2009. Clin Rheumatol. 28: 1441-2. PMID: 19727918
8. Identification of Differential Expression Cytokines in Hemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome by Proteome Microarray Analysis and Further Verification.  |  Kang, S., et al. 2021. Cell Transplant. 30: 963689720975398. PMID: 33757334
9. Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.  |  Briggs, MD., et al. 1995. Nat Genet. 10: 330-6. PMID: 7670472
10. Characterization of human and mouse cartilage oligomeric matrix protein.  |  Newton, G., et al. 1994. Genomics. 24: 435-9. PMID: 7713493
11. Distribution and expression of cartilage oligomeric matrix protein and bone sialoprotein show marked changes during rat femoral head development.  |  Shen, Z., et al. 1995. Matrix Biol. 14: 773-81. PMID: 8785592

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Thrombospondin 5 Antibody (F-7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Thrombospondin 5 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Thrombospondin 5 Antibody (F-7) Specifications

Alternate Product Name: Thrombospondin 5

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-110

Epitope Target: Thrombospondin 5

Epitope Species: human

Product Reactivity/Detection: Thrombospondin 5 (also designated COMP)

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Thrombospondin 5 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin