Thrombospondin 5 Antibody (644A8D5): sc-33696

Thrombospondin 5 Antibody (644A8D5) is a mouse monoclonal IgG2a antibody that detects Thrombospondin 5 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Thrombospondin 5, also known as cartilage oligomeric matrix protein (COMP), plays a crucial role in the structural integrity of cartilage and connective tissues, making anti-Thrombospondin 5 antibody (644A8D5) essential for studying the extracellular matrix. Thrombospondin 5 is primarily located in the extracellular matrix of cartilage, tendon, and vascular smooth muscle, where Thrombospondin 5 is developmentally regulated and localized to the chondrocyte territorial and interterritorial matrix. Proper localization of Thrombospondin 5 is vital for binding to Collagen Types I, II, and IX in a zinc-dependent manner, which is important for the stability and organization of the extracellular matrix. Mutations in the COMP/THBS5 gene can lead to serious genetic disorders such as pseudoachondroplasia and multiple epiphyseal dysplasia, both of which are characterized by skeletal abnormalities and can result in significant health issues. Thrombospondin 5 monoclonal antibody (644A8D5) is an invaluable tool for researchers investigating cartilage biology and related pathologies.

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Thrombospondin 5 Antibody (644A8D5) References:

1. Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.  |  Chen, FH., et al. 2005. J Biol Chem. 280: 32655-61. PMID: 16051604
2. Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.  |  Chen, FH., et al. 2007. J Biol Chem. 282: 24591-8. PMID: 17588949
3. Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells.  |  Haleem-Smith, H., et al. 2012. J Cell Biochem. 113: 1245-52. PMID: 22095699
4. Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins.  |  Halper, J. and Kjaer, M. 2014. Adv Exp Med Biol. 802: 31-47. PMID: 24443019
5. Pseudoachondroplasia/COMP - translating from the bench to the bedside.  |  Posey, KL., et al. 2014. Matrix Biol. 37: 167-73. PMID: 24892720
6. Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease.  |  Fu, Y. and Kong, W. 2017. Curr Vasc Pharmacol. 15: 186-196. PMID: 28155614
7. Thrombospondin-5 and fluvastatin promote angiogenesis and are protective against endothelial cell apoptosis.  |  Muqri, F., et al. 2020. J Cell Biochem. 121: 4154-4165. PMID: 32348623
8. Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.  |  Andrés Sastre, E., et al. 2021. Bone. 150: 115999. PMID: 33971315
9. Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta.  |  Forte-Gomez, HF., et al. 2022. Front Endocrinol (Lausanne). 13: 1000662. PMID: 36452329
10. TMF inhibits extracellular matrix degradation by regulating the C/EBPβ/ADAMTS5 signaling pathway in osteoarthritis.  |  Wang, Z., et al. 2024. Biomed Pharmacother. 174: 116501. PMID: 38554527

The preferred Thrombospondin 5 antibody is Thrombospondin 5 Antibody (F-7): sc-374660.