Thrombin API Antibody (B-4): sc-271586
- Thrombin API Antibody (B-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 71-157 mapping near the N-terminus of Thrombin Activation Peptide 1 of mouse origin
- recommended for detection of Thrombin API and Prothrombin of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Thrombin API Antibody (B-4) for WB applications. These reagents are now offered in bundles with Thrombin API Antibody (B-4) (see ordering information below).
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Thrombin API Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects Thrombin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Thrombin plays a crucial role in the hemostatic process, primarily by converting fibrinogen into fibrin, which is essential for clot formation. This conversion is vital not only for stopping bleeding but also for initiating wound healing and tissue repair. Thrombin is predominantly found in the bloodstream, where activated platelets and endothelial cells secrete this protein, highlighting Thrombin′s importance in maintaining vascular integrity and regulating blood flow. Additionally, Thrombin is involved in various signaling pathways that influence cell proliferation and differentiation, making Thrombin a key player in both hemostasis and tissue regeneration. Anti-Thrombin antibody (B-4) provides reliable detection of Thrombin, facilitating research into its multifaceted roles in coagulation and beyond.
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Thrombin API Antibody (B-4) References:
- Inhibition of osteoblast apoptosis by thrombin. | Pagel, CN., et al. 2003. Bone. 33: 733-43. PMID: 14555279
- A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. | Bompiani, KM., et al. 2012. J Thromb Haemost. 10: 870-80. PMID: 22385910
- Comparative behavior of thrombin and an inactive derivative, FPR-thrombin, toward the rabbit vascular endothelium. Heparin liberates FPR-thrombin from the endothelium in vivo. | Hatton, MW. and Moar, SL. 1990. Circ Res. 67: 221-9. PMID: 2364492
- Effects of thrombin and thrombin receptor activation on cardiac function after acute myocardial infarction. | Gu, X., et al. 2015. Am J Transl Res. 7: 654-69. PMID: 26064435
- pHAST (pH-Driven Aptamer Switch for Thrombin) Catch-and-Release of Target Protein. | McConnell, EM., et al. 2016. Bioconjug Chem. 27: 1493-9. PMID: 27115292
- Reversible Photocontrol of Thrombin Activity by Replacing Loops of Thrombin Binding Aptamer using Azobenzene Derivatives. | Mo, M., et al. 2019. Bioconjug Chem. 30: 231-241. PMID: 30582682
- Conversion of thrombin into an anticoagulant by protein engineering. | Gibbs, CS., et al. 1995. Nature. 378: 413-6. PMID: 7477382
- Regulation of thrombin activity by antithrombin and heparin. | Olson, ST. and Björk, I. 1994. Semin Thromb Hemost. 20: 373-409. PMID: 7899869
- Understanding thrombin and hemostasis. | Fenton, JW., et al. 1993. Hematol Oncol Clin North Am. 7: 1107-19. PMID: 8294310
- Thrombin stimulation of matrix fibronectin. | Armstrong, MT., et al. 1996. J Cell Physiol. 166: 112-20. PMID: 8557759
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombin API Antibody (B-4) | sc-271586 | 200 µg/ml | $316.00 | |||
Thrombin API Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-537666 | 200 µg Ab; 10 µg BP | $354.00 | |||
Thrombin API Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-535005 | 200 µg Ab; 40 µg BP | $354.00 | |||
Thrombin API Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-545293 | 200 µg Ab; 20 µg BP | $354.00 |