THP Antibody (B-5): sc-271023

THP Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects Tamm-Horsfall glycoprotein (THP) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). THP is the most abundant protein found in normal urine, synthesized by kidney epithelial cells, and plays a crucial role in maintaining renal water balance, immunosuppression, and preventing urinary stone formation. Notably, THP is anchored to the luminal surface of the renal epithelium via a glycosyl phosphatidylinositol (GPI) anchor and is excreted in urine at a rate of 50-100 mg per day. THP′s ability to inhibit bacterial adhesion is particularly important for preventing urinary tract infections, while THP′s interaction with other urinary glycoproteins, such as uropontin and nephrocalcin, highlights THP′s role in modulating calcium dynamics and stone formation in the kidneys. The gene encoding THP, which is located on human chromosome 16p12.3, is also a candidate gene for nephrolithiasis, underscoring THP′s significance in both health and disease. With diverse functions and critical involvement in urinary system physiology, anti-THP antibody (B-5) is an essential tool for researchers studying renal function and related disorders.

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THP Antibody (B-5) References:

1. The role of Tamm-Horsfall glycoprotein and Nephrocalcin in calcium oxalate monohydrate crystallization processes.  |  Hess, B. 1991. Scanning Microsc. 5: 689-95; discussion 696. PMID: 1808706
2. Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.  |  Renigunta, A., et al. 2011. J Biol Chem. 286: 2224-35. PMID: 21081491
3. Tamm-Horsfall glycoprotein enhances PMN phagocytosis by binding to cell surface-expressed lactoferrin and cathepsin G that activates MAP kinase pathway.  |  Siao, SC., et al. 2011. Molecules. 16: 2119-34. PMID: 21372759
4. Tamm Horsfall glycoprotein in diabetes mellitus: abnormal chemical composition and colloid stability.  |  Rambausek, M., et al. 1988. Eur J Clin Invest. 18: 237-42. PMID: 3138126
5. Tamm-Horsfall glycoprotein in human amniotic fluid.  |  Phimister, GM. and Marshall, RD. 1983. Clin Chim Acta. 128: 261-9. PMID: 6406102
6. The physiologic and pathologic roles of Tamm-Horsfall glycoprotein in urinary system.  |  Yu, CL. and Tsai, CY. 1995. Gaoxiong Yi Xue Ke Xue Za Zhi. 11: 481-95. PMID: 7474032
7. Tamm-Horsfall glycoprotein in streptozotocin diabetic rats: a study of kidney in situ hybridization, immunohistochemistry, and urinary excretion.  |  Rasch, R., et al. 1995. Diabetologia. 38: 525-35. PMID: 7489834
8. Purification of a 92 kDa human immunostimulating glycoprotein obtained from the Tamm-Horsfall glycoprotein.  |  Fontan, E., et al. 1995. J Immunol Methods. 187: 81-4. PMID: 7490460
9. Tamm-Horsfall glycoprotein and calcium nephrolithiasis.  |  Hess, B. 1994. Miner Electrolyte Metab. 20: 393-8. PMID: 7783702
10. Tamm-Horsfall glycoprotein binds IgG with high affinity.  |  Rhodes, DC., et al. 1993. Kidney Int. 44: 1014-21. PMID: 8264130

The preferred THP antibody is THP Antibody (B-2): sc-271022.