Tyrosine Hydroxylase Antibody (A-6): sc-374048

TH Antibody (A-6) is a mouse monoclonal IgM antibody that detects tyrosine hydroxylase (TH) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TH is a critical enzyme that catalyzes the conversion of tyrosine to L-dopa, representing the rate-limiting step in the biosynthesis of catecholamines, including dopamine, adrenaline, and noradrenaline. TH (A-6) antibody is essential for studying normal levels of these neurotransmitters, which are vital for various physiological processes, including mood regulation, stress response, and motor control. Dysregulation of TH activity has been implicated in the pathogenesis of neurological disorders, particularly Parkinson′s disease, where reduced dopamine levels lead to significant motor and cognitive impairments. Additionally, TH gene regulation involves transcription factor binding sites such as the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), which respond to various signaling pathways. Anti-TH antibody (A-6) serves as an invaluable tool for researchers studying the intricate mechanisms of catecholamine biosynthesis and its implications in health and disease.

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Tyrosine Hydroxylase Antibody (A-6) References:

1. Expression of tyrosine hydroxylase and vasopressin in magnocellular neurons of salt-loaded aged rats.  |  Marsais, F., et al. 2002. Microsc Res Tech. 56: 81-91. PMID: 11810711
2. Phosphorylation and activation of tyrosine hydroxylase in PC18 cells: a cell line derived from rat pheochromocytoma PC12 cells.  |  Bowyer, JF., et al. 1992. Brain Res. 591: 261-70. PMID: 1359923
3. Effects of mutations in tyrosine hydroxylase associated with progressive dystonia on the activity and stability of the protein.  |  Royo, M., et al. 2005. Proteins. 58: 14-21. PMID: 15468323
4. Four forms of tyrosine hydroxylase are present in human adrenal medulla.  |  Haycock, JW. 1991. J Neurochem. 56: 2139-42. PMID: 1674001
5. Use of microdialysis for monitoring tyrosine hydroxylase activity in the brain of conscious rats.  |  Westerink, BH., et al. 1990. J Neurochem. 54: 381-7. PMID: 1967629
6. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes.  |  Skjevik, AA., et al. 2014. J Mol Biol. 426: 150-68. PMID: 24055376
7. Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase.  |  Lee, KY., et al. 1989. J Neurochem. 53: 1238-44. PMID: 2570128
8. Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector.  |  Ginns, EI., et al. 1988. J Biol Chem. 263: 7406-10. PMID: 2896667
9. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.  |  Zhou, QY., et al. 1995. Nature. 374: 640-3. PMID: 7715703
10. Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies.  |  Xu, ZQ., et al. 1998. Neuroscience. 82: 727-38. PMID: 9483531

The preferred Tyrosine Hydroxylase antibody is Tyrosine Hydroxylase Antibody (F-11): sc-25269.