TGIF2 Antibody (H-36): sc-81989
- TGIF2 Antibody (H-36) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant TGIF2 of human origin
- recommended for detection of TGIF2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TGIF2 Antibody (H-36). This work is in progress.
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TGIF2 Antibody (H-36) is a mouse monoclonal IgG2a antibody that detects TGIF2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TGIF2, also known as TGFβ-induced factor homeobox 2 or 5′-TG-3′-interacting factor 2, is a crucial protein predominantly expressed in the kidney, heart, and testis, and plays a significant role in regulating gene expression by acting as a transcriptional repressor. Localized in the nucleus, TGIF2 contains a homeobox DNA-binding domain that allows binding to specific DNA sequences, thereby influencing the transcription of target genes. TGIF2 interacts with histone deacetylases, particularly HDAC1, and the transcriptional modulator Smad3, which are essential for mediating the repression of TGFβ-responsive genes. TGIF2′s function is crucial in developmental processes; mutations in the TGIF2 gene can lead to holoprosencephaly, a serious condition characterized by the incomplete development of the forebrain. Additionally, TGIF2 overexpression in certain ovarian cancers suggests a role in tumorigenesis, making TGIF2 a potential target for therapeutic intervention. With insights into both normal developmental biology and disease mechanisms, anti-TGIF2 antibody (H-36) serves as an invaluable tool for researchers studying gene regulation and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TGIF2 Antibody (H-36) | sc-81989 | 100 µg/ml | $333.00 |