TGF beta 2 Antibody (B-10): sc-374658

TGFβ2 Antibody (B-10) is a mouse monoclonal IgG3 kappa light chain antibody that detects TGFβ2 from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TGFβ2 antibody (B-10) is available in non-conjugated form. Transforming growth factor β2 (TGFβ2) plays a crucial role in various biological processes, including cell proliferation, differentiation, and immune regulation, making TGFβ2 essential for maintaining tissue homeostasis and mediating responses to injury. TGFβ2 is primarily secreted by various cell types, including fibroblasts and epithelial cells, and is found in the extracellular matrix, where TGFβ2 influences cellular behavior and communication. Proper functioning of TGFβ2 is vital, as dysregulation can lead to pathological conditions such as fibrosis, cancer, and autoimmune diseases. TGFβ2 is synthesized as a precursor protein that undergoes cleavage to produce a biologically active form, which requires dimerization for activity. Mature TGFβ2 shares significant structural similarities with TGFβ1 and TGFβ3, highlighting the evolutionary conservation of function across species. With an ability to mediate critical signaling pathways, TGFβ2 is a key player in developmental processes and tissue repair, making TGFβ2 (B-10) antibody an invaluable tool for researchers studying these complex biological mechanisms.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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TGF beta 2 Antibody (B-10) References:

1. TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.  |  Takahashi, H., et al. 2019. Nat Metab. 1: 291-303. PMID: 31032475
2. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells.  |  Corbet, C., et al. 2020. Nat Commun. 11: 454. PMID: 31974393
3. TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.  |  Sun, T., et al. 2021. Sci Transl Med. 13: PMID: 34349032
4. Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGFβ2.  |  Nobre, AR., et al. 2021. Nat Cancer. 2: 327-339. PMID: 34993493
5. YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction.  |  Li, H., et al. 2022. Invest Ophthalmol Vis Sci. 63: 15. PMID: 36350617
6. Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.  |  Goodwin, AT., et al. 2023. Development. 150: PMID: 37102682
7. miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway.  |  Yang, Z., et al. 2023. Cancer Biol Ther. 24: 2281459. PMID: 37981873
8. MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.  |  Zheng, H., et al. 2024. Mol Oncol. 18: 1327-1346. PMID: 38383842
9. A tumor-promotional molecular axis CircMAPKBP1/miR-17-3p/TGFβ2 activates autophagy pathway to drive tongue squamous cell carcinoma cisplatin chemoresistance.  |  Xie, S., et al. 2024. Cancer Lett. 604: 217230. PMID: 39276917
10. TGFβ2-Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions.  |  Oh, SJ., et al. 2024. Adv Sci (Weinh). 11: e2400660. PMID: 39481440

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TGFβ2 Antibody (B-10) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-TGFβ2 Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TGFβ2 Antibody (B-10) Specifications

Alternate Product Name: TGFβ2

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 343-377

Epitope Target: TGFβ2

Epitope Species: human

Product Reactivity/Detection: mature and precursor forms of TGFβ2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for TGFβ2 Antibody (B-10): P: Blocking Peptide

The preferred TGFβ2 antibody is TGFβ2 Antibody (H-6): sc-374659.