TGFβ2 Antibody (H-6): sc-374659

TGFβ2 Antibody (H-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects TGFβ2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TGFβ2 antibody (H-6) is available as the non-conjugated form. TGFβ2 protein plays a crucial role in various cellular processes, including cell proliferation, differentiation, and extracellular matrix production, making TGFβ2 essential for tissue homeostasis and repair. TGFβ2 is primarily secreted by various cell types and is found in the extracellular matrix, where TGFβ2 influences the behavior of surrounding cells through autocrine and paracrine signaling. TGFβ2 is particularly important during embryonic development, as TGFβ2 regulates the formation of various tissues and organs. Additionally, TGFβ2 is involved in the immune response and has been implicated in fibrotic diseases and cancer progression, highlighting TGFβ2′s significance in both normal physiology and pathological conditions. The mature TGFβ2 protein is produced as a precursor that undergoes cleavage to yield a biologically active form, which requires dimerization for activity. With diverse roles in cellular communication and development, TGFβ2 remains a key focus of research in understanding various diseases and therapeutic interventions.

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TGFβ2 Antibody (H-6) References:

1. Transforming growth factor-beta. A family of growth regulatory peptides.  |  Miller, DA., et al. 1990. Ann N Y Acad Sci. 593: 208-17. PMID: 2375595
2. Molecular characterization of transforming growth factor type beta 3.  |  ten Dijke, P., et al. 1990. Ann N Y Acad Sci. 593: 26-42. PMID: 2375596
3. Recombinant TGF-beta 1 is synthesized as a two-component latent complex that shares some structural features with the native platelet latent TGF-beta 1 complex.  |  Wakefield, LM., et al. 1989. Growth Factors. 1: 203-18. PMID: 2629880
4. TGFβ2-induced senescence during early inner ear development.  |  Gibaja, A., et al. 2019. Sci Rep. 9: 5912. PMID: 30976015
5. Identification of another member of the transforming growth factor type beta gene family.  |  ten Dijke, P., et al. 1988. Proc Natl Acad Sci U S A. 85: 4715-9. PMID: 3164476
6. TGFβ2-mediated epithelial-mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance.  |  Jiang, XM., et al. 2021. Acta Pharmacol Sin. 42: 451-459. PMID: 32678313
7. Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.  |  de Martin, R., et al. 1987. EMBO J. 6: 3673-7. PMID: 3322813
8. Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells.  |  Tran, MN., et al. 2023. Life (Basel). 13: PMID: 37511956
9. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.  |  Derynck, R., et al. Nature. 316: 701-5. PMID: 3861940
10. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.  |  Todaro, GJ., et al. 1980. Proc Natl Acad Sci U S A. 77: 5258-62. PMID: 6254071
11. Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.  |  Anzano, MA., et al. 1983. Proc Natl Acad Sci U S A. 80: 6264-8. PMID: 6604914
12. Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q.  |  Nishimura, DY., et al. 1993. Genomics. 15: 357-64. PMID: 8095486

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TGFβ2 Antibody (H-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TGFβ2 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TGFβ2 Antibody (H-6) Specifications

Alternate Product Name: TGFB2

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 343-377

Epitope Target: TGFβ2

Epitope Species: human

Product Reactivity/Detection: mature and precursor forms of TGFβ2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TGFβ2 Antibody (H-6): P: Blocking Peptide

The preferred TGFβ3 antibody is TGFβ3 Antibody (G-9): sc-166833.