TGF beta Receptor 1/TGFBR1 Antibody (C-12): sc-518086

TGFβ RI Antibody (C-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects TGFβ RI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TGFβ RI antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TGFβ RI, a 503 amino acid single-pass type I membrane protein, plays a crucial role in the transforming growth factor-beta (TGFβ) signaling pathway, which is essential for regulating cell growth, differentiation, and immune responses. TGFβ RI is primarily located on the cell surface, where TGFβ RI interacts with the type II receptor to form a functional receptor complex that initiates downstream signaling cascades. Proper functioning of TGFβ RI is vital for maintaining cellular homeostasis, and defects in TGFβ RI can lead to severe conditions such as aortic aneurysm familial thoracic type 5 and Loeys-Dietz syndrome. TGFβ RI monoclonal antibody (C-12) enables researchers to gain insights into the TGFβ signaling pathway and its implications in various diseases, making TGFβ RI (C-12) antibody an invaluable tool for both basic and translational research.

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TGF beta Receptor 1/TGFBR1 Antibody (C-12) References:

1. Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis.  |  Khalil, N., et al. 2001. Thorax. 56: 907-15. PMID: 11713352
2. [Expression of TGF beta 1 and TGF beta RI proteins in tissues of salivary adenoid cystic carcinoma].  |  Guo, F., et al. 2002. Hunan Yi Ke Da Xue Xue Bao. 27: 229-32. PMID: 12575299
3. Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase.  |  Ottesen, JJ., et al. 2004. Biochemistry. 43: 5698-706. PMID: 15134444
4. Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells.  |  Ammanamanchi, S. and Brattain, MG. 2004. J Biol Chem. 279: 32620-5. PMID: 15155736
5. TGF-beta 1 inhibits mast cell Fc epsilon RI expression.  |  Gomez, G., et al. 2005. J Immunol. 174: 5987-93. PMID: 15879091
6. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats.  |  Laping, NJ., et al. 2007. Clin Cancer Res. 13: 3087-99. PMID: 17505012
7. TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.  |  Mohammad, KS., et al. 2011. Cancer Res. 71: 175-84. PMID: 21084275
8. An in silico study on pulmonary fibrosis inhibitors from Tinospora cordifolia and Curcuma longa targeting TGF-β RI.  |  Annam, N., et al. 2023. J Biomol Struct Dyn. 41: 3145-3161. PMID: 35068362
9. Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy.  |  Xu, H., et al. 2022. J Pharm Anal. 12: 860-868. PMID: 36605575
10. Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha.  |  Gordon, JR. and Galli, SJ. 1994. J Exp Med. 180: 2027-37. PMID: 7964480

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TGF beta Receptor 1/TGFBR1 Antibody (C-12) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TGF beta Receptor 1/TGFBR1 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TGF beta Receptor 1/TGFBR1 Antibody (C-12) Specifications

Alternate Product Name: TGFBR1

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 26-125

Epitope Target: TGFβ RI

Epitope Species: human

Product Reactivity/Detection: TGFβ RI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TGF beta Receptor 1/TGFBR1 Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin